IL6

Gene Information
 
Gene Symbol
IL6
 
Aliases
BSF2, HGF, HSF, IFNB2, IL-6
 
Entrez Gene ID
 
Gene Name
Interleukin 6
 
Chromosomal Location
7p21-p15
 
HGNC ID
 
Summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0002384 Biological process Hepatic immune response TAS 12832423
GO:0002446 Biological process Neutrophil mediated immunity IC 16034137
GO:0002548 Biological process Monocyte chemotaxis IC 10510402
GO:0002675 Biological process Positive regulation of acute inflammatory response IDA 2444978
GO:0002690 Biological process Positive regulation of leukocyte chemotaxis IC 16034137
Protein Information
 
Protein Name
Interleukin-6
 
Function
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00489 IL6 Interleukin-6/G-CSF/MGF family
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Acute pancreatitis 9058297, 16633121, 10508122, 9918438, 7679365, 15617304, 16001614, 12960727, 1427382, 15103565, 9934758, 17075990, 7902182, 8981500, 8665189, 19220961, 7587812, 10206482, 1907253, 11777983, 8813775, 20214338, 11185709, 7651717, 11577303, 15877240, 16567468, 9511087, 10795756, 10231842, 10628606, 9759598, 8244123, 17207355, 8119637, 17214932, 19273184, 18388680, 10986216, 9598821, 16473521, 17450041, 14726612, 12604912, 11957802, 11566005, 10875461, 17031111, 16495704, 15753607, 11900675, 11159890, 10881937, 10711463, 20110745, 20397261, 15556304, 14561181, 11954822, 8402063, 17376050, 16111089, 14566081, 10667507, 7908847, 18217404, 20485254
Anemia 18336871, 12232842, 20019408, 15741985, 15897306, 10907020, 18309490, 9474133, 12588568, 1602292, 9589749, 7919369, 9263142, 7542502, 15995969, 20406921, 16374277, 9029005, 11503575, 8809240, 18664788, 8619442, 19854855, 17391480, 17119383, 15593047, 12209693, 7542377, 1993216, 19915946, 11424663, 7794747, 20470305, 19265263, 18547996, 18923748, 17951471, 17468076, 16617859, 17160447, 16261603, 16479095, 15893120, 15576267, 11598887, 9785361, 9000479, 7632934, 20184247, 19384207, 18632918, 18676162, 18260177, 17260180, 8178944, 8492420, 19586961, 19752376, 17341272, 17441472, 12406898, 11886383, 15774616, 10870116, 9704253, 15989626, 8528047, 18788432, 16314788, 14990112, 12799213, 10466349, 10444359, 7628876, 16408206, 15277149, 10774463, 9309197, 18407769, 12633573, 9787323, 8852036, 2392639, 16676010, 17978466
Arthritis 1752286, 1398781, 20042455, 12960484, 18534002, 19327240, 1556702, 17075601, 19035481, 9463396, 11469477, 17405296, 9375540, 11606449, 10623431, 9010263, 7848306, 17495100, 16690760, 11578019, 19297421, 17028666, 2359995, 19109734, 2170644, 1606750, 18397956, 20042581, 15934843, 15705788, 15628047, 12746890, 11922199, 11014358, 9291340, 1612762, 7562749, 18955278, 19180491, 18664393, 17911637, 15751095, 15258981, 12761229, 12562400, 19227651, 18974624, 17708739, 17374166, 17567894, 17239366, 17028817, 17028799, 16572453, 15604610, 16142877, 15517632, 15501766, 15312124, 12522051, 11954886, 9759522, 8596143, 1304740, 20410258, 8006883, 19117174, 15251133, 11742208, 10921508, 10747905, 9375862, 9224431, 9007485, 19866480, 18388517, 17966396, 16277693, 16142848, 15843582, 15570632, 10693865, 9933631, 8474061, 1934688, 19849822, 18446012, 9159238, 14613283, 14607859, 12220549, 7520139, 1550404, 2381137, 19570240, 19365268, 18473869, 16133581, 16196481, 7944637, 16582692, 9410434, 18419107, 10547275, 18336871, 2012076, 7520139, 2057724, 1531188, 9115749, 9182920, 1930911, 10653854, 8597883, 1947669, 1934684, 2359995, 7738942, 19635908, 11155809, 10340005, 16815861, 11145851, 10381038, 9184265, 8336307, 1602292, 1690543, 7911833, 18358926, 11128925, 9350293, 8961377, 2019746, 7702403, 14513800, 12483717, 11196696, 11093434, 8744678, 1376492, 2242066, 8457224, 18784373, 17708739, 16572284, 16728461, 12903526, 11037876, 8393676, 11578019, 11120852, 10329846, 7639799, 18799095, 18024284, 20444632, 7677445, 20029652, 16287931, 11155806, 1752286, 18375536, 18759290, 12873794, 8187811, 1556702, 12793958, 12010778, 16844318, 16920570, 16899107, 16095005, 15868610, 15647428, 15039637, 15188351, 12730964, 1380241, 1643291, 1601643, 1667942, 1707461, 2392639, 7562749, 20306675, 20046013, 16196481, 16097634, 15934843, 15996076, 15871661, 12960348, 12902519, 12550108, 12148597, 1418006, 19535263, 2057724, 7520139, 11593916, 12873794, 7488982, 2381137, 16815861, 17476620, 11093434, 20393674, 19663194, 1376492, 2109776, 1531188, 8091128, 7586981, 18257935, 1752286, 7752112, 9876901, 7948616, 17937463, 16198603, 12550108, 11922199, 9481895, 9263143, 9026271, 8079829, 16734121, 12211691, 11108572, 10064394, 10721101, 9032818, 8154312, 20175976, 7668899, 19403407, 18312558, 17911635, 12673891, 10693867, 1398781, 2335234, 2104896, 18759291, 15820616, 15104599, 12960491, 12228163, 9272300, 8737721, 2242066, 17640966, 10679127, 9375862, 17262819, 15642131, 14680510, 12379189, 11455121, 1292640, 19333684, 15307384, 8886087, 7562749, 8717100, 9182920, 10452831, 11883975, 12010778, 9045866, 17075601, 9489807, 20410258, 1622424, 8731234, 9769329, 7531125, 9776110, 8308784, 9489833, 9770335, 15815691, 1930333, 8731233, 8187333, 11960642, 11024553, 1458703, 7699643, 18974624, 15364891, 11520812, 9309198, 10505742, 8639855, 8982123, 12739045, 18473869, 7788176, 12220549, 7473488
Atherosclerosis 17604035, 15557373, 11677362, 15050298, 16087797, 12923954, 15969253, 15064106, 16275545, 17618612, 15935563, 12482836, 16463434, 16518702, 10542237, 19877084, 17684929, 16685208, 17196470, 12452316, 20064818, 16900203, 19652871, 8003639, 14612208, 9242962, 9721534, 9769329, 10657556, 15953127, 16466124, 9721532, 9108797, 20515802, 19723903, 18487068, 18539932, 18279814, 15876998, 16786783, 10469050, 19438975, 19079838, 19168721, 17924848, 17441409, 17190908, 16467451, 16669409, 15088418, 15320841, 14624957, 9626133, 19619183, 19602903, 16487030, 16600299, 16424352, 11076827, 10747905, 10436255, 8907298, 19940327, 19339995, 19284547, 19130178, 18392379, 12574550, 11402968, 18928057, 17919644, 18281810, 17636056, 16889573, 16357111, 15826936, 15161792, 15381186, 14609022, 12736161, 11840367, 11383376, 19766217, 20110287, 19936194, 19436757, 17592552, 17472849, 17255532, 15978151, 15963066, 11835030, 11590255, 16477056, 15911740, 15005271, 14612201, 12508095, 11849469
Autoimmune diseases 1864011, 12220549, 9195514, 10225680, 1627787, 19758168, 19715447, 7578871, 19209259, 18992196, 2191052, 1593179, 8625551, 9693973, 1868982, 7757333, 8813336, 17028666, 16542377, 12373879, 9843988, 20421913, 19319845, 19365268, 19127457, 15934843, 16899108, 11357886, 11288043, 8336306, 1380488, 2188060, 19038405, 17493366, 17708740, 16227151, 12476893, 9338013, 9214425, 7875195, 1865759, 2086490, 18974624, 19143195, 7508509, 19604260, 17289547, 16247179, 11992589, 10922080, 10720455, 15992152, 19483409, 18071945, 17110312, 18958646, 16767291, 12461182, 15989626, 7513204, 1355612, 17569223, 17192581, 9701844, 8173768, 8251150, 8219666, 8371004, 1690543, 19307104, 17465721, 8639818, 7936613, 2127356, 15115315, 17978466, 18280640, 18470720
   
References
 
Primary:

A common interleukin-6 gene promoter polymorphism influences the clinical characteristics of women with polycystic ovary syndrome.

Walch Katharina, Grimm Christoph, Zeillinger Robert, Huber Johannes C, Nagele Friedrich, Hefler Lukas A
Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria. katharina.walch@meduniwien.ac.at
Fertil Steril. 2004 Jun;81(6):1638-41.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
SHBG 
Insulin sensitivity 
 
Rotterdam criteria 
Related 
 
sIL-6R concentration was lower (P = 0.0036) in women with PCOS independently of obesity 
 
PCOS 
-174 G/C 
 
Related 
97 Turkish PCOS, 95 Turkish controls 
The study suggests that IL-6 promoter region polymorphism may be related to occurrence and metabolic abnormalities seen in PCOS in the Turkish population 
 
PCOS, obesity 
 
 
Related 
40 women with PCOS and 40 age-matched controls 
In this study, serum IL-6 levels were found to be higher in women with PCOS as compared to controls 
IL10, TGF- 1,  
 
1082A/G (IL10), -819A/T(IL10), -522A/G (IL10),-1082A/G (IL10), +874T/A (IFN- ), 10T/C (TGF- 1),-179C/G (IL6),  
 
Related 
97 with PCOS, 99 controls 
The genetic polymorphisms of cytokines are not associated with PCOS development, but may contribute to common metabolic disorders associated with PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26320144
Effects of metformin on mitochondrial function of leukocytes from polycystic ovary syndrome patients with insulin resistance. 
Effect of treatment 
26292090, PMC4548699
Levels of Neopterin and other Inflammatory Markers in Obese and Non-Obese Patients with Polycystic Ovary Syndrome. 
Clinical study 
26188541
Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients. 
Effect of treatment 
26177495
Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. 
Clinical study 
26158655
Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors. 
Clinical study 

 

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