IL5

Gene Information
 
Gene Symbol
IL5
 
Aliases
EDF, IL-5, TRF
 
Entrez Gene ID
 
Gene Name
Interleukin 5
 
Chromosomal Location
5q23-q31
 
HGNC ID
 
Summary
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. (provided by RefSeq, Jul 2013)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0071803 Biological process Positive regulation of podosome assembly IDA 15220135
GO:0005615 Cellular component Extracellular space TAS 3024129
GO:0005515 Molecular function Protein binding IPI 1495999
Protein Information
 
Protein Name
Interleukin-5
 
Function
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF02025 IL5 Interleukin 5
 
OMIM

Associated Diseases

Diseases References
Inflammation 17716857
   
References
 
Primary:

Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome.

Benson S, Janssen O E, Hahn S, Tan S, Dietz T, Mann K, Pleger K, Schedlowski M, Arck P C, Elsenbruch S
Department of Medical Psychology & Behavioral Immunobiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany.
Brain Behav Immun. 2008 Feb;22(2):177-84. Epub 2007 Aug 22.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IL-6,stimulated production of IFN-gamma, IL-2, IL-4, TNF-alpha ,IL-10, leukocyte numbers and hsCRP 
Cardiovascular risk,obesity and inflammation 
 
 
Related 
 
The stimulated production of IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-5 was significantly decreased, irrespective of BMI. 

 

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