IL1A

Gene Information
 
Gene Symbol
IL1A
 
Aliases
IL-1A, IL1, IL1-ALPHA, IL1F1
 
Entrez Gene ID
 
Gene Name
Interleukin 1, alpha
 
Chromosomal Location
2q14
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006915 Biological process Apoptotic process TAS 1924307
GO:0006954 Biological process Inflammatory response TAS 6209582
GO:0008283 Biological process Cell proliferation TAS 6209582
GO:0008285 Biological process Negative regulation of cell proliferation IDA 3493774
GO:0019221 Biological process Cytokine-mediated signaling pathway IMP 2989698
Protein Information
 
Protein Name
Interleukin 1, alpha
 
Function
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00340 IL1 Interleukin-1 / 18
PF02394 IL1_propep Interleukin-1 propeptide
 
OMIM

Associated Diseases

Diseases References
Acantholysis 12930304, 17624241, 10082594
Acne vulgaris 1830734
Alopecia areata 8977716, 11703512
Alzheimers disease 7830934, 7494597, 15201366, 12794386, 12722921, 12218254, 10953173, 12928052, 11079552, 18717723, 17149369, 15377701, 12231216, 1453878, 12947160, 10953177, 17473736, 11065142, 12759172
Arthritis 11120857, 11342576, 8033415, 14688369, 16278818, 19333931, 9007485, 15316669, 7848306, 12522051, 1304740, 17567894, 9916738, 8054359, 8995911, 16332240, 10792391, 8782124, 1863828, 2398274, 1458286, 8608352, 7540690, 9347881, 11083259, 11930657, 14750259, 16277680, 8737721, 9876392, 7633938, 8162643, 1427978, 1879083, 16901957, 11192540, 1593571, 11155806, 9350293, 16829497, 12522051, 10834861, 2258613, 1730100, 8783415, 10229398, 10728755, 16278818, 1969779, 9283970, 11511685, 10229398, 16278818, 1969779, 1458286, 11247873, 8737721, 8185691, 9776110, 10342632, 8668960, 7558921, 7699643, 16829497, 8995911
   
References
 
Primary:

Interleukin-1 alpha but not interleukin-1 beta gene polymorphism is associated with polycystic ovary syndrome.

Kolbus Andrea, Walch Katharina, Nagele Friedrich, Wenzl Rene, Unfried Gertrud, Huber Johannes C
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. andrea.kolbus@meduniwien.ac.at
J Reprod Immunol. 2007 Apr;73(2):188-93. Epub 2006 Sep 11.

 

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