IGFBP4

Gene Information
 
Gene Symbol
IGFBP4
 
Aliases
BP-4, HT29-IGFBP, IBP4, IGFBP-4
 
Entrez Gene ID
 
Gene Name
Insulin-like growth factor binding protein 4
 
Chromosomal Location
17q12-q21.1
 
HGNC ID
 
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001501 Biological process Skeletal system development TAS 1377672
GO:0006259 Biological process DNA metabolic process TAS 1377672
GO:0007165 Biological process Signal transduction TAS 1377672
GO:0008283 Biological process Cell proliferation TAS 1377672
Protein Information
 
Protein Name
Insulin-like growth factor-binding protein 4
 
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00086 Thyroglobulin_1 Thyroglobulin type-1 repeat
PF00219 IGFBP Insulin-like growth factor binding protein
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000269593 P22692

Associated Diseases

Diseases References
Atresia 8530645, 8949894
Bone loss 9795371, 16397738, 10652019, 8817691
Diabetes mellitus 9795371
Hyperthyroidism 11380497
Hypothyroidism 11380497
   
References
 
Primary:

Serum and follicular fluid levels of IGF-II, IGF-binding protein-4 and pregnancy-associated plasma protein-A in controlled ovarian hyperstimulation cycle between polycystic ovarian syndrome (PCOS) and non-PCOS women.

Zhong Gang, Chen Biheng
Department of Obstetric and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. gzhongwh@yahoo.com
Gynecol Endocrinol. 2011 Feb;27(2):86-90. Epub 2010 Jun 8.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IGFBPs 
 
 
 
Related 
 
IGFBP-2, IGFBP-4, and the 29K BP are significantly increased in PCO FF 
 
 
 
 
Related 
12womens with rgular menstrual cycle 
The decrease in IGF-I-mediated stimulation of gonadotropin actions on granulosa and theca cells in preantral and antral follicles may impair the induction of aromatase activity, causing an androgenic microenvironment which is characteristic of atretic follicles and PCOS follicles. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
20528206
Serum and follicular fluid levels of IGF-II, IGF-binding protein-4 and pregnancy-associated plasma protein-A in controlled ovarian hyperstimulation cycle between polycystic ovarian syndrome (PCOS) and non-PCOS women. 
Clinical study 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412