IGFBP3

Gene Information
 
Gene Symbol
IGFBP3
 
Aliases
BP-53, IBP3
 
Entrez Gene ID
 
Gene Name
Insulin-like growth factor binding protein 3
 
Chromosomal Location
7p13-p12
 
HGNC ID
 
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001933 Biological process Negative regulation of protein phosphorylation IDA 17591901
GO:0006468 Biological process Protein phosphorylation IDA 17434920
GO:0008285 Biological process Negative regulation of cell proliferation IGI 19258508
GO:0009968 Biological process Negative regulation of signal transduction NAS 11940579
GO:0014912 Biological process Negative regulation of smooth muscle cell migration IDA 10766744
Protein Information
 
Protein Name
Insulin-like growth factor-binding protein 3
 
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00086 Thyroglobulin_1 Thyroglobulin type-1 repeat
PF00219 IGFBP Insulin-like growth factor binding protein
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Acquired hypothyroidism 9689829
Acromegaly 7586626, 9231047, 10195375, 7533774, 8971551, 11555849, 9389990, 11847474, 9814451, 10560262, 12201224, 14700556, 10427158, 11238491, 9628244, 10573632, 7519529, 9160813, 9076345, 7513781, 11914026, 8657365, 14964446, 20009494, 19401363, 15259383, 12641631, 10443687, 9024241, 11942776, 10090134, 18458708, 15698601, 11527090, 17336738, 19494714, 16127208, 11443159, 11318786, 11531924
Anorexia nervosa 12629097, 1381372, 16737142, 7523649, 10199777, 12792153
Anovulation 12542168, 25721191
Atresia 8612491, 9096890, 8530645
   
References
 
Primary:
PMID: 7534239

Alterations in the sensitivity of serum insulin-like growth factor 1 and insulin-like growth factor binding protein-3 to octreotide in polycystic ovary syndrome.

Morris R S, Carmina E, Vijod M A, Stanczyk F Z, Lobo R A
University of Southern California, Los Angeles.
Fertil Steril. 1995 Apr;63(4):742-6.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
Rotterdam criteria 
Direct 
35 women with PCOS, 30 controls  
In PCOS women, serum leptin, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3 levels and the insulin resistance index (HOMA-IR) were significantly higher 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
22473412, PMC3297040
Assessing the benefits of rosiglitazone in women with polycystic ovary syndrome through its effects on insulin-like growth factor 1, insulin-like growth factor-binding protein-3 and insulin resistance: a pilot study. 
Effect of treatment 
21543511
In vivo oocyte developmental competence is reduced in lean but not in obese superovulated dairy cows after intraovarian administration of IGF1. 
Animal study 
20926690
Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor. 
In vitro 

 

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