IGFBP2

Gene Information
 
Gene Symbol
IGFBP2
 
Aliases
IBP2, IGF-BP53
 
Entrez Gene ID
 
Gene Name
Insulin-like growth factor binding protein 2, 36kDa
 
Chromosomal Location
2q33-q34
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0042104 Biological process Positive regulation of activated T cell proliferation IDA 15694994
GO:0005615 Cellular component Extracellular space IDA 15694994
GO:0005515 Molecular function Protein binding IPI 19095771
GO:0031994 Molecular function Insulin-like growth factor I binding IDA 19081843
Protein Information
 
Protein Name
Insulin-like growth factor-binding protein 2
 
Function
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00086 Thyroglobulin_1 Thyroglobulin type-1 repeat
PF00219 IGFBP Insulin-like growth factor binding protein
 
OMIM

Associated Diseases

Diseases References
Atresia 8530645
Polycystic ovary syndrome (PCOS) 12095507, 1383254
   
References
 
Primary:

Regulation of insulin-like growth factor binding protein secretion by human granulosa luteal cells in a polycystic ovary-like environment.

Greisen Susanne, Flyvbjerg Allan, Ledet Thomas, Ovesen Per
Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark. greisens@mail1.stofanet.dk
Fertil Steril. 2002 Jul;78(1):162-8.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IGFBP-1,IGFBP-4 
 
 
 
Related 
 
These results demonstrate that androgen and insulin are important regulators of IGFBP release and that elevated levels of the two hormones may contribute to the altered IGFBP profile found in PCOS follicles, compared with the case of estrogen-dominant follicles. 
IGFBP-3,IGFBP-4 and TGF-beta  
 
 
 
Related 
 
The results of this studies indicate that IGFBP-2, IGFBP-4, and the 29K BP are significantly increased in PCO FF and that gonadotropins and TGF-beta regulate the production of IGFBPs by human theca and granulosa cells. 
IGFBP-3,IGFBP-4 
Atresia 
 
 
Related 
 
These data support the hypothesis that decreased concentrations of IGFBP, in particular IGFBP-3, may be involved in selection of the dominant follicle, and that when a spontaneous pre-ovulatory follicle develops in PCOS, the underlying cause of the polycystic ovaries is not resolved but the rest of the ovary remains polycystic. 

 

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