IGFBP1

Gene Information
 
Gene Symbol
IGFBP1
 
Aliases
AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1
 
Entrez Gene ID
 
Gene Name
Insulin-like growth factor binding protein 1
 
Chromosomal Location
7p13-p12
 
HGNC ID
 
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 2454104
Protein Information
 
Protein Name
Insulin-like growth factor binding protein 1
 
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00086 Thyroglobulin_1 Thyroglobulin type-1 repeat
PF00219 IGFBP Insulin-like growth factor binding protein
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000275525 P08833

Associated Diseases

Diseases References
Acromegaly 1713220, 7544670, 1715247, 11238491, 7525123, 7513781, 14700556
Atherosclerotic plaque 9484994
Bone loss 9795371
Cancer (carcinoma) 19199270, 1695798, 9536279, 25348852
Cardiovascular diseases 15963068, 15505005, 16448523, 11972304, 17803702, 11248749, 10704627, 16019358, 15598684, 12145180, 14715837, 17224001, 19917654
   
References
 
Primary:
PMID: 1283982

The role of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 (IGFBP-1) in the pathogenesis of polycystic ovary syndrome.

Homburg R, Pariente C, Lunenfeld B, Jacobs H S
Department of Obstetrics and Gynaecology, Golda Medical Centre, Petah Tikva, Israel.
Hum Reprod. 1992 Nov;7(10):1379-83.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
SHBG  
 
 
 
Related 
21 PCO, 18 obese women without menstrual disturbances and 9 Control 
obese women with PCO insulin influence ovarian androgen production and decreases the serum SHBG and IGFBP-1 which could contribute in the augmentation of the symptoms of PCO 
IGF-1 and IGF 
 
 
 
Related 
10 PCOS, 12 hypopituitarism and 10 Control 
Women with PCOS have normal serum IGF-1 concentrations but IGFBP-1 levels, regulated by insulin, are low 
 
 
 
 
Related 
 
Decreased serum level of IGFBP-1 is unlikely to be a mechanism for ovarian hyperandrogenism in PCOS 
Matrix metalloproteinases(MMPs) 
 
 
 
Related 
42 PCOS and 30 Control 
MMPs may be implicated in the pathophysiology of PCOS either by regulating ovarian tissue remodeling or indirectly by facilitating IGF-I bioavailability through proteolysis of IGFBP-1 
Glycodelin  
 
 
PCOS was diagnosed before pregnancy, and defined by oligomenorrhea (eight or fewer menstrual periods annually before pregnancy) and hyperandrogenism (elevated serum free testosterone concentration or hirsutism) 
Related 
72 PCOS and 62 Control 
During the first trimester, serum glycodelin and IGFBP-1 concentrations are markedly decreased in PCOS, implicating endometrial epithelial and stromal dysfunction during periimplantation and early pregnancy as a possible mechanism for EPL in PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25750105, PMC4400200
Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. 
In vitro 
21962963
Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome. 
Effect of treatment 

 

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