IGF1

Gene Information
 
Gene Symbol
IGF1
 
Aliases
IGF-IA, IGFI, IGF1
 
Entrez Gene ID
 
Gene Name
Insulin-like growth factor 1 (somatomedin C)
 
Chromosomal Location
12q23.2
 
HGNC ID
 
Summary
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001501 Biological process Skeletal system development TAS 10448861
GO:0006260 Biological process DNA replication TAS 10766744
GO:0006916 Biological process Anti-apoptosis IDA 16942485
GO:0006928 Biological process Cellular component movement TAS 10766744
GO:0007165 Biological process Signal transduction TAS 10448861
Protein Information
 
Protein Name
Insulin-like growth factor I
 
Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00049 Insulin Insulin/IGF/Relaxin family
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions

Associated Diseases

Diseases References
Acanthosis nigricans 9876344, 11244342
Acromegaly 17575366, 17047383, 7586626, 17431794, 10195375, 18037753, 9231047, 11555849, 1715247, 11701684, 8971551, 12670296, 16815351, 12914750, 8050134, 19336510, 14700556, 12864793, 8018009, 12186455, 18284644, 9389990, 18248639, 14764751, 9814451, 11847474, 15080775, 11940041, 8223982, 12029573, 10427158, 1517371, 1559300, 19798623, 17980002, 15760781, 14671148, 11232010, 17458702, 16114283, 15761230, 10999811, 16159936, 16625853, 14971738, 10843197, 7865627, 15765031, 11443159, 10651750, 9329336, 19060447, 17429594, 12201224, 12175092, 19411301, 17546251, 12138989, 8514980, 15070920, 15761238, 16625852, 18524797, 1562170, 1521515, 11078980, 7852509, 1517833, 19739577, 17692168, 17573420, 16932333, 15671111, 15080777, 14557452, 12721507, 7513781, 19226264, 17077948, 18418712, 18401209, 17218728, 16125529, 14499709, 12914744, 12812310, 11936466, 9160813, 19634028, 19661126, 11182746, 10372698, 9135706, 17429590, 17077131, 16575760, 16498061, 15817912, 15191332
Amyotrophic lateral sclerosis 12660059, 17943766, 19029516, 10896693, 19845745, 15094865, 8282084, 8883943, 9710040, 18855638, 20157530, 15193297, 19323791, 17116217, 19198769, 18719018, 19572220, 15990113, 18608100, 19634028, 7595602, 16197815, 17597610, 17963733
Anovulation 10775198, 9002642, 9493087, 15950665, 10375231, 1283982, 12542168
Cancer (adenoma) 19472104, 7691862, 14710344, 16926522, 15104560, 11499662, 15301564, 1355729, 8413819, 9405903, 7670568, 18840925, 17270100, 10883914, 10507079, 9467544, 1611713, 18991502, 10374130, 19617182, 17425608, 16821203, 15542931, 17671378, 16061823, 17542527, 17024157, 10372703, 19293545, 11979395, 1717961, 12460458, 10794477, 18559566, 18250342, 11136321, 16083703, 17679371, 10937058, 10999811, 10999841, 17530416, 10507079, 10498342, 1506622, 11904318, 1702931, 8669808, 7689191, 12807513, 11081174, 9302367, 8413819, 2172274, 18230656, 16625850, 16172212, 15104560, 14585094, 16649981, 16335261, 15891957, 15803901, 12433739, 10984283, 17159821, 15497658, 15174237, 9467544, 9435450, 10592442, 16967359, 16118335, 15677710, 15765031, 15761660, 11972303, 20335450, 15585629, 7691862, 1717961, 12516247, 8240671
   
References
 
Primary:

Elevated ghrelin plasma levels in patients with polycystic ovary syndrome.

Wasko R, Komarowska H, Warenik-Szymankiewicz A, Sowinski J
Department of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poland. endonucl@mail.am.poznan.pl
Horm Metab Res. 2004 Mar;36(3):170-3.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IGFBP-1 
hypopituitarism 
 
 
Related 
women with PCOS (n = 10), hypopituitarism (n = 12) and normal controls (n = 10) 
Patients with PCOS could be separated into those with high LH and those with high insulin levels. It was concluded that women with PCOS have normal serum IGF-1 concentrations but IGFBP-1 levels, regulated by insulin, are low. Hyperinsulinaemia and raised LH are independently capable of stimulating ovarian androgen production. Growth factors may have an important role in the pathogenesis of PCOS. 
VEGF 
 
 
 
Related 
50 infertile women with PCOS and 20healthy control 
Higher serum levels of VEGF and IGF-1 in PCOS women may be related to the increased vascularity that underlies the increased blood flow demonstrated by Doppler blood flow measurements in these women. 
leptin  
hyperinsulinemia  
 
 
Related 
46 PCOS-HI and 46 PCOS-NHI 
The leptin and IGF-1 may contribute to the pathogenesis of PCOS, but the relationship between leptin, IGF-1 and hyperinsulinemia needs more researches to confirm. 
IGFBP-3 
 
 
 
Related 
11 women with PCOS and 6 matched ovulatory controls 
PCOS may be more sensitive to the effects of octreotide in decreasing IGF-1 and increasing IGFBP-3 
 
 
 
 
Related 
9 women with PCOS and one patient with multicystic ovaries 
IGF1 has a paracrine role in the regulation of ovarian function in the human female. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25999995, PMC4426143
Influence of ??-3 fatty acid eicosapentaenoic acid on IGF-1 and COX-2 gene expression in granulosa cells of PCOS women. 
Effect of treatment 
25902782, PMC4476412
Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling. 
Animal study 
25667201
Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome. 
Animal study 
25539545
Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism. 
Clinical study 
24943040
Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: role in IGF-1-induced steroidogenesis through NAMPT. 
In vitro 

 

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