HSPE1

Gene Information
 
Gene Symbol
HSPE1
 
Aliases
CPN10, EPF, GROES, HSP10
 
Entrez Gene ID
 
Gene Name
Heat shock 10kDa protein 1
 
Chromosomal Location
2q33.1
 
HGNC ID
 
Summary
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.(provided by RefSeq, Feb 2011)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006919 Biological process Activation of cysteine-type endopeptidase activity involved in apoptotic process NAS 10205158
GO:0006986 Biological process Response to unfolded protein TAS 7698325
GO:0005515 Molecular function Protein binding IPI 18319262
GO:0051082 Molecular function Unfolded protein binding NAS 12483302
Protein Information
 
Protein Name
10 kDa heat shock protein, mitochondrial
 
Function
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00166 Cpn10 Chaperonin 10 Kd subunit
 
OMIM
   
References
 
Primary:

Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.

Fan Lu, Fan Lu, Ling Jing, Ma Xiang, Cui Yu-Gui, Liu Jia-Yin
Jiangsu Province Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Gynecol Endocrinol. 2009 Jun;25(6):392-7.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Follicular development 
 
 
Related 
 
HSP10 was highly expressed in normal ovaries compared with those from PCOS. The mouse early antral follicle culture approach may help to understand the role of HSP10 in pathophysiological development of PCOS. 

 

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