HP

Gene Information
 
Gene Symbol
HP
 
Aliases
BP2ALPHA2, HPA1S, HP
 
Entrez Gene ID
 
Gene Name
Haptoglobin
 
Chromosomal Location
16q22.2
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006952 Biological process Defense response TAS 7036344
GO:0010942 Biological process Positive regulation of cell death IDA 19740759
GO:0042542 Biological process Response to hydrogen peroxide IDA 19740759
GO:0051354 Biological process Negative regulation of oxidoreductase activity IDA 19740759
GO:2000296 Biological process Negative regulation of hydrogen peroxide catabolic process IDA 19740759
Protein Information
 
Protein Name
Zonulin , BP , haptoglobin, alpha polypeptide , Zonulin , HP2ALPHA2 , binding peptide , HPA1S , haptoglobin, beta polypeptide , haptoglobin alpha(1S)-beta , haptoglobin alpha(2FS)-beta , haptoglobin
 
Function
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00089 Trypsin Trypsin
 
OMIM

Associated Diseases

Diseases References
Chronic inflammation 19440331
Obesity 19440331
Polycystic ovary syndrome (PCOS) 20484478
   
References
 
Primary:

Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women.

Alvarez-Blasco Francisco, Martinez-Garcia Ma Angeles, Luque-Ramirez Manuel, Parraza Naiara, San Millan Jose L, Escobar-Morreale Hector F
Department of Endocrinology, Hospital Universitario Ramon y Cajal & Universidad de Alcala, Madrid, Spain.
PLoS One. 2009;4(5):e5606. doi: 10.1371/journal.pone.0005606. Epub 2009 May 19.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Obesity, insulin resistance and chronic inflammation 
Hp(2) alleles 
Androgen Excess Society criteria 
Related 
 
The association of polycystic ovary syndrome with Hp(2) alleles suggests that the anti-oxidant and anti-inflammatory properties of haptoglobin may be reduced in these patients. 
Alpha2-macroglobulin,transferrin 
 
 
NIH, Rotterdam and Androgen Excess and PCOS Society criteria 
Related 
 
Proteomic analysis of plasma from PCOS patients revealed changes in protein expression in several acute-phase response proteins including isoforms of plasma haptoglobin, alpha2-macroglobulin, and transferrin and in kappa-free light chain. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26269538
Androgen levels in women with various forms of ovarian dysfunction: associations with cardiometabolic features. 
Clinical study 
25450303
Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study. 
Clinical study 
25385669, PMC4414383
Patients' administration preferences: progesterone vaginal insert (Endometrin??) compared to intramuscular progesterone for Luteal phase support. 
Effect of treatment 
24876842, PMC4021745
The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance. 
Effect of treatment 
24397393
Validation of proteomic biomarkers previously found to be differentially expressed in women with polycystic ovary syndrome: a cross-sectional study. 
Clinical study 

 

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