HOXA10

Gene Information
 
Gene Symbol
HOXA10
 
Aliases
HOX1, HOX1.8, HOX1H, PL
 
Entrez Gene ID
 
Gene Name
Homeobox A10
 
Chromosomal Location
7p15.2
 
HGNC ID
 
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007283 Biological process Spermatogenesis TAS 7700356
GO:0005515 Molecular function Protein binding IPI 18692240
Protein Information
 
Protein Name
Homeobox protein Hox-A10
 
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00046 Homeobox Homeobox domain
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000283921 P31260

Associated Diseases

Diseases References
Cancer (endometrial carcinoma) 15627890, 11875117, 12489992
Cryptorchidism 10037424, 14960020
Endometriosis 19736237, 18829447, 16647375, 17350963
Infertility 19736237, 11953062, 9525980, 10981664
Pregnancy loss 19389728
   
References
 
Primary:

Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome.

Cermik Dilek, Selam Belgin, Taylor Hugh S
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
J Clin Endocrinol Metab. 2003 Jan;88(1):238-43.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
22576737
HOXA10 expression is decreased by testosterone in luteinized granulosa cells in vitro. 
In vitro 

 

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