HMOX1

Gene Information
 
Gene Symbol
HMOX1
 
Aliases
HMOX1D, HO-1, HSP32, bK286B10
 
Entrez Gene ID
 
Gene Name
Heme oxygenase (decycling) 1
 
Chromosomal Location
22q12
 
HGNC ID
 
Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001525 Biological process Angiogenesis TAS 12239590
GO:0001935 Biological process Endothelial cell proliferation TAS 12239590
GO:0002246 Biological process Wound healing involved in inflammatory response IMP 9884342
GO:0002686 Biological process Negative regulation of leukocyte migration TAS 14525760
GO:0006788 Biological process Heme oxidation IDA 17915953
Protein Information
 
Protein Name
Heme oxygenase 1
 
Function
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01126 Heme_oxygenase Heme oxygenase
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Insulin resistance 21148661
   
References
 
Primary:

Expression levels of haem oxygenase-1 in the omental adipose tissue and peripheral blood mononuclear cells of women with polycystic ovary syndrome.

Seow Kok-Min, Lin Yu-Hung, Hwang Jiann-Loung, Wang Peng-Hui, Ho Low-Tone, Lin Yi-Hsiu, Juan Chi-Chang
Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC.
Hum Reprod. 2011 Feb;26(2):431-7. doi: 10.1093/humrep/deq351. Epub 2010 Dec 10.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Insulin resistance and glucose tolerance 
 
Rotterdam criteria 
Related 
 
Our results suggest that the HO-1-adiponectin axis may be associated with the regulation of insulin resistance and glucose intolerance in women with PCOS. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25068085, PMC4110095
Gene expression in subcutaneous adipose tissue differs in women with polycystic ovary syndrome and controls matched pair-wise for age, body weight, and body mass index. 
Clinical study 

 

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