GSTT1

Gene Information
 
Gene Symbol
GSTT1
 
Entrez Gene ID
 
Gene Name
Glutathione S-transferase theta 1
 
Chromosomal Location
22q11.23 alternate reference locu
 
HGNC ID
 
Summary
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0005829 Cellular component Cytosol IDA 8799324
GO:0004602 Molecular function Glutathione peroxidase activity IDA 9307035
Protein Information
 
Protein Name
Glutathione S-transferase theta-1 , glutathione transferase T1-1 , Glutathione transferase T1-1 , OTTHUMP00000198549 , OTTHUMP00000198547 , GST class-theta-1 , glutathione S-transferase theta 1 , EC 2.5.1.18
 
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00043 GST_C Glutathione S-transferase, C-terminal domain
PF02798 GST_N Glutathione S-transferase, N-terminal domain
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000401632 P30711

Associated Diseases

Diseases References
Allergic reaction 15300848, 15612961
Alzheimers disease 10215103
Anemia aplastic 11719393, 16079101, 14681495
Asthma 19086569, 15612961, 15639977, 20134034, 16409207, 15300848, 12173466, 20032267, 17497028, 10840461, 18057098, 17711870, 15148962, 17651144, 16550944, 11234415, 15223862, 11862323, 11202642, 20073549, 20049212, 16164441, 12018173
Bladder tumors 19467981, 18690546
   
References
 
Primary:

CYP1A1, GSTM1 and GSTT1 genetic polymorphism is associated with susceptibility to polycystic ovaries in South Indian women.

Babu K Arvind, Rao K Lakshmi, Kanakavalli M K, Suryanarayana V V, Deenadayal Mamata, Singh Lalji
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, AP, India.
Reprod Biomed Online. 2004 Aug;9(2):194-200.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
CYP1A1 and GSTM1 
 
 
 
Related 
180 women with confirmed PCO and in 72 healthy fertile women 
In conclusion, the presence of hyperinducible CYP1A1 (T6235C) mutant genotype and its mutants in combination with GSTM1 and GSTT1 null genotypes might cause an imbalance between phase I and phase II enzymes, and therefore may represent a risk factor for PCO. 
CYP1A1, GSTM1 
 
CYP1A1 (T6235C), GSTM1[-] and GSTT1[-] 
 
Related 
254 South Indian women (180 PCO, 72 controls) 
The study concludes that the presence of hyperinducible CYP1A1 (T6235C) mutant genotype and its mutants in combination with GSTM1 and GSTT1 null genotypes might cause an imbalance between phase I and phase II enzymes, and therefore may represent a risk factor for PCO 

 

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