GSTM3

Gene Information
 
Gene Symbol
GSTM3
 
Aliases
GST5, GSTB-3, GTM3, GSTM3
 
Entrez Gene ID
 
Gene Name
Glutathione S-transferase mu 3 (brain)
 
Chromosomal Location
1p13.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006749 Biological process Glutathione metabolic process IDA 10587441
GO:0008065 Biological process Establishment of blood-nerve barrier TAS 2345169
GO:0018916 Biological process Nitrobenzene metabolic process IDA 8373352
GO:0042178 Biological process Xenobiotic catabolic process IDA 8373352
GO:0043627 Biological process Response to estrogen IEP 10037815
Protein Information
 
Protein Name
Glutathione S-transferase Mu 3
 
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00043 GST_C Glutathione S-transferase, C-terminal domain
PF02798 GST_N Glutathione S-transferase, N-terminal domain
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Insulin resistance 21521935
Visceral adiposity 18156650
   
References
 
Primary:

Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry.

Corton Marta, Botella-Carretero Jose I, Lopez Juan A, Camafeita Emilio, San Millan Jose L, Escobar-Morreale Hector F, Peral Belen
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, E-28029 Madrid, Spain.
Hum Reprod. 2008 Mar;23(3):651-61. Epub 2007 Dec 22.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Proapolipoprotein Apo-A1, annexin V,PRDX2,triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein 
Visceral adiposity 
 
Presence of oligo-ovulation, clinical and/or biochemical hyperandrogenism, and exclusion of hyperprolactinemia, non-classic congenital adrenal hyperplasia and androgen-secreting tumors  
Related 
 
This preliminary study revealed differences in expression of proteins that may be involved in lipid and glucose metabolism, oxidative stress processes and adipocyte differentiation; they include proapolipoprotein Apo-A1, annexin V, glutathione S-transferase M3 (GSTM3), triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein. 
DHEAS, SHBG, 2-h plasma glucose,malondialdehyde (MDA), protein carbonyl (PC), reduced glutathione (GSH), carotene, vitamin A, C, E and the enzyme activities of catalase 
Oxidative stress,Insulin resistance and Hyperglycemia 
 
 
Related 
 
Oxidative stress characterized by increased oxidants and decreased antioxidant levels which are independent of IR may be involved in the pathogenesis of PCOS in young non-obese women. 

 

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