GSTM1

Gene Information
 
Gene Symbol
GSTM1
 
Aliases
GST1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, GSTM1
 
Entrez Gene ID
 
Gene Name
Glutathione S-transferase mu 1
 
Chromosomal Location
1p13.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006749 Biological process Glutathione metabolic process IDA 8373352
GO:0018916 Biological process Nitrobenzene metabolic process IDA 8373352
GO:0042178 Biological process Xenobiotic catabolic process IDA 8373352
GO:0070458 Biological process Cellular detoxification of nitrogen compound IDA 8373352
GO:0005737 Cellular component Cytoplasm IDA 8373352
Protein Information
 
Protein Name
Glutathione S-transferase mu 1
 
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00043 GST_C Glutathione S-transferase, C-terminal domain
PF02798 GST_N Glutathione S-transferase, N-terminal domain
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Alzheimers disease 7640148, 10215103
Anemia aplastic 11719393, 16079101, 15291288, 11463560, 16173971
Asbestosis 9055949
Cancer (carcinoma) 1747943, 11792413, 9139841, 20359083, 11463560, 18093316, 16112301, 19160101, 19467981, 10506106, 19669596
Cleft lip 16521944, 16135950
   
References
 
Primary:

CYP1A1, GSTM1 and GSTT1 genetic polymorphism is associated with susceptibility to polycystic ovaries in South Indian women.

Babu K Arvind, Rao K Lakshmi, Kanakavalli M K, Suryanarayana V V, Deenadayal Mamata, Singh Lalji
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, AP, India.
Reprod Biomed Online. 2004 Aug;9(2):194-200.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
CYP1A1, GSTT1 
 
CYP1A1 (T6235C), GSTM1[-] and GSTT1[-] 
 
Related 
253 (180 PCO, 72 controls) 
The study concludes that the presence of hyperinducible CYP1A1 (T6235C) mutant genotype and its mutants in combination with GSTM1 and GSTT1 null genotypes might cause an imbalance between phase I and phase II enzymes, and therefore may represent a risk factor for PCO 

 

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