GNRH1

Gene Information
 
Gene Symbol
GNRH1
 
Aliases
GNRH, GRH, HH12, LHRH, LNRH
 
Entrez Gene ID
 
Gene Name
Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
 
Chromosomal Location
8p21-p11.2
 
HGNC ID
 
Summary
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH), also known as gonadoliberin-1, and prolactin release-inhibiting factor, also known as GnRH-associated peptide 1. LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 8692981
GO:0007267 Biological process Cell-cell signaling TAS 1310542
GO:0008285 Biological process Negative regulation of cell proliferation TAS 10832105
GO:0005179 Molecular function Hormone activity TAS 2863757
Protein Information
 
Protein Name
GnRH-associated peptide 1
 
Function
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00446 GnRH Gonadotropin-releasing hormone
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000276414 P01148

Associated Diseases

Diseases References
Cancer (adenoma) 9177416, 7746355, 11037346, 8162161, 8550798, 7704445, 8496331, 1679762, 8496331, 9177416, 2118538, 8200967, 7858734, 7892662, 7704445, 16832587, 2177142, 8127416
Central diabetes insipidus 9675568
Endocrine disorder 12586422
Gonadal dysfunction 8449185
Hypothyroidism juvenile 15112911, 10960339
   
References
 
Primary:
PMID: 8692506

Induction of ovulation in clomiphene-resistant polycystic ovary syndrome with pulsatile GnRH.

Tan S L, Farhi J, Homburg R, Jacobs H S
Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Canada.
Obstet Gynecol. 1996 Aug;88(2):221-6.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
LH, FSH, FSHR, testosterone 
 
Trp16Ser [rs6185] 
Rotterdam criteria 
Related 
518 Caucasian PCOS women and 2996 controls 
Genetic variants of the HPG-axis were associated with a modest but significant effect on the phenotype of PCOS 
LH 
 
 
 
Direct 
151 PCOS patients, 34 controls  
Women with PCOS have higher baseline and GnRH-stimulated LH concentrations. GnRH stimulation results in an increase in LH/FSH ratio in women with PCOS. Therefore we postulate that this phenomenon might be potentially useful as an additional tool in the diagnosis ofPCOS 

 

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