GIP

Gene Information
 
Gene Symbol
GIP
 
Entrez Gene ID
 
Gene Name
Gastric inhibitory polypeptide
 
Chromosomal Location
17q21.3-q22
 
HGNC ID
 
Summary
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 2890159
Protein Information
 
Protein Name
Gastric inhibitory polypeptide
 
Function
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR000532
 
Pfam
Pfam Accession Pfam ID
PF00123 Hormone_2 Peptide hormone
 
OMIM

Associated Diseases

Diseases References
Diabetes mellitus type 2 21671782, 18511472
   
References
 
Primary:

The incretin effect and secretion in obese and lean women with polycystic ovary syndrome: a pilot study.

Pontikis Charalambos, Yavropoulou Maria P, Toulis Konstantinos A, Kotsa Kalliopi, Kazakos Kyriakos, Papazisi Aleka, Gotzamani-Psarakou Anna, Yovos John G
Division of Clinical Endocrinology and Metabolism, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 S. Kyriakidi Street, Thessaloniki, Greece.
J Womens Health (Larchmt). 2011 Jun;20(6):971-6. doi: 10.1089/jwh.2010.2272.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
GLP-1,C-peptide 
Insulin resistance,type 2 diabetes 
 
 
Related 
 
Increased insulinotropic effect could counteract the blunted GIP response to OGTT in obese women with PCOS. 
GLP-1,C-peptide 
Type 2 diabetes 
 
 
Related 
 
Increased total GIP and lower late phase active GLP-1 concentrations during OGTT characterize PCOS women with higher C-peptide secretion in comparison with healthy controls, and may be the early markers of a pre-diabetic state. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25029417
Circulating irisin and glucose-dependent insulinotropic peptide are associated with the development of polycystic ovary syndrome. 
Clinical study 

 

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