GHRH

Gene Information
 
Gene Symbol
GHRH
 
Aliases
GHRF, GRF, INN
 
Entrez Gene ID
 
Gene Name
Growth hormone releasing hormone
 
Chromosomal Location
20q11.2
 
HGNC ID
 
Summary
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007267 Biological process Cell-cell signaling TAS 6192430
GO:0008284 Biological process Positive regulation of cell proliferation IDA 12867592
GO:0019933 Biological process CAMP-mediated signaling IDA 7680413
GO:0030252 Biological process Growth hormone secretion IDA 2857452
GO:0030819 Biological process Positive regulation of cAMP biosynthetic process IDA 1333056
Protein Information
 
Protein Name
Somatoliberin
 
Function
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR000532
 
Pfam
Pfam Accession Pfam ID
PF00123 Hormone_2 Peptide hormone
 
OMIM

Associated Diseases

Diseases References
Acromegaly 10483668, 1683501, 19017754, 16968791, 17598976, 1281259, 7939340, 10604121, 9768668, 11165046, 1922854, 7991070
Cancer (adenoma) 7745020, 1350590, 1363983, 9109848, 2060147, 1352308, 12807513, 16595604, 1350590, 1683501, 9392350, 1923952, 16968791, 9162246, 12679459, 2291627
Cancer (carcinoma) 11710593, 11920625, 11390017, 16968791, 15853821
Cushing syndrome 7828354
Diabetes mellitus insulin-dependent 1727733
   
References
 
Primary:
PMID: 8959075

Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome.

Micic D, Kendereski A, Popovic V, Sumarac M, Zoric S, Macut D, Dieguez C, Casanueva F
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Beograd, Yugoslavia.
Clin Endocrinol (Oxf). 1996 Oct;45(4):385-90.

 

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