GATA6

Gene Information
 
Gene Symbol
GATA6
 
Entrez Gene ID
 
Gene Name
GATA binding protein 6
 
Chromosomal Location
18q11-q12
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0000122 Biological process Negative regulation of transcription from RNA polymerase II promoter IDA 18177748
GO:0003148 Biological process Outflow tract septum morphogenesis IMP 19666519
GO:0006351 Biological process Transcription, DNA-dependent IDA 19497978
GO:0008584 Biological process Male gonad development IEP 17848411
GO:0042493 Biological process Response to drug IMP 18671946
Protein Information
 
Protein Name
Transcription factor GATA-6
 
Function
Thought to be important for regulating terminal differentiation and/or proliferation
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00320 GATA GATA zinc finger
PF05349 GATA-N GATA-type transcription activator, N-terminal
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000269216 Q92908

Associated Diseases

Diseases References
Adrenal tumor 15767045, 17207921, 14666170
Cancer (carcinoma) 18227727, 15767045, 15666845, 18769116, 15666845, 15767045
   
References
 
Primary:

Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells.

Ho Clement K M, Wood Jennifer R, Stewart Douglas R, Ewens Kathryn, Ankener Wendy, Wickenheisser Jessica, Nelson-Degrave Velen, Zhang Zhibing, Legro Richard S, Dunaif Andrea, McAllister Jan M, Spielman Richard, Strauss Jerome F 3rd
Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
J Clin Endocrinol Metab. 2005 Dec;90(12):6596-602. Epub 2005 Sep 13.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
mRNA levels 
 
 
Related 
469 families that contain at least one PCOS  
PCOS theca cells, GATA6 gene transcription and the stability of the GATA6 mRNA are increased 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25591557
Identification of differentially expressed microRNAs in the ovary of polycystic ovary syndrome with hyperandrogenism and insulin resistance. 
In vitro 

 

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