FSHB

Gene Information
 
Gene Symbol
FSHB
 
Aliases
HH24
 
Entrez Gene ID
 
Gene Name
Follicle stimulating hormone, beta polypeptide
 
Chromosomal Location
11p13
 
HGNC ID
 
Summary
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006701 Biological process Progesterone biosynthetic process TAS 14557487
GO:0007165 Biological process Signal transduction TAS 8220432
GO:0007179 Biological process Transforming growth factor beta receptor signaling pathway IEP 14557487
GO:0007292 Biological process Female gamete generation TAS 8220432
GO:0007565 Biological process Female pregnancy TAS 8220432
Protein Information
 
Protein Name
Follitropin subunit beta
 
Function
Stimulates development of follicle and spermatogenesis in the reproductive organs
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00007 Cys_knot Cystine-knot domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Azoospermia 16730882
Cancer (adenoma) 2118538, 9666878, 8881451, 9143002, 1419353, 7513714, 9820613, 8881451, 1902844, 1375599
Hypogonadism 19966036, 9271483, 12568849, 20067895
Infertility 11299519, 16730882, 17227474
Pituitary tumors 1902844, 1375599
   
References
 
Primary:

Association of AccI polymorphism in the follicle-stimulating hormone beta gene with polycystic ovary syndrome.

Tong Y, Liao W X, Roy A C, Ng S C
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Singapore.
Fertil Steril. 2000 Dec;74(6):1233-6.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26416764
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. 
Clinical study 
26284813, PMC4557132
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. 
Clinical study 
26203175
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. 
Animal study 
21076077, PMC3043129
PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. 
Animal study 
20980683
Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA). 
Animal study 

 

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