FLT1

Gene Information
 
Gene Symbol
FLT1
 
Aliases
FLT, FLT-1, VEGFR-1, VEGFR1
 
Entrez Gene ID
 
Gene Name
Fms-related tyrosine kinase 1
 
Chromosomal Location
13q12
 
HGNC ID
 
Summary
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007169 Biological process Transmembrane receptor protein tyrosine kinase signaling pathway TAS 2158038
GO:0007565 Biological process Female pregnancy TAS 10194760
GO:0008284 Biological process Positive regulation of cell proliferation TAS 10748050
GO:0030949 Biological process Positive regulation of vascular endothelial growth factor receptor signaling pathway IDA 1312256
GO:0005615 Cellular component Extracellular space TAS 8248162
Protein Information
 
Protein Name
FLT , Tyrosine-protein kinase FRT , VEGFR1 , fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , OTTHUMP00000018183 , VEGFR-1 , vascular permeability factor receptor , vascular endothelial growth factor receptor 1 , Tyrosine-protein kinase receptor FLT , FRT , tyrosine-protein kinase FRT , tyrosine-protein kinase receptor FLT , Fms-like tyrosine kinase 1 , FLT-1 , Vascular permeability factor receptor , fms-like tyrosine kinase 1 , EC 2.7.10.1
 
Function
Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF07679 I-set Immunoglobulin I-set domain
PF07714 Pkinase_Tyr Protein tyrosine kinase
PF13895 Ig_2 Immunoglobulin domain
 
KEGG
 
OMIM
 
Interactions

Associated Diseases

Diseases References
Arthritis 11592367, 12091877, 12898512, 11592367, 19180491, 20108506, 16336962
Asthma 18421428, 16528018, 17105777
Atherosclerosis 19948974, 11834138, 17109193, 12898512
Cancer (carcinoma) 19834490, 19287991, 10831352, 11330643, 11480589, 8644848, 18041747, 15700836, 9669344, 9058706, 11734454
Choroidal neovascularization 20053138, 16195702, 18368052, 19778186
   
References
 
Primary:

Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review.

Peitsidis Panagiotis, Agrawal Rina
The Royal Free and University College Medical School, University College London, Gower Street, London, UK.
Reprod Biomed Online. 2010 Apr;20(4):444-52. Epub 2010 Jan 14.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Direct 
 
This review concluded that VEGF may have a strategic role in the pathophysiology of PCOS and is the key mediator in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) in women undergoing assisted reproductive procedures. Its role is perhaps not singular and several other factors such as the bioavailability of its soluble receptor sFlt-1 and a multidisciplinary orchestration of other cytokines and growth factors may be involved in the pathophysiology of PCOS and OHSS. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26178718
Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep? 
Animal study 
25141961, PMC4150963
Follicular fluid placental growth factor is increased in polycystic ovarian syndrome: correlation with ovarian stimulation. 
Clinical study 
24144948
Advanced glycation end products as an upstream molecule triggers ROS-induced sFlt-1 production in extravillous trophoblasts: a novel bridge between oxidative stress and preeclampsia. 
In vitro 
23899470
Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia. 
In vitro 
20697141
Follicular fluid-specific distribution of vascular endothelial growth factor isoforms and sFlt-1 in patients undergoing IVF and their correlation with treatment outcomes. 
Effect of treatment 

 

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