F3

Gene Information
 
Gene Symbol
F3
 
Aliases
CD142, TF, TFA
 
Entrez Gene ID
 
Gene Name
Coagulation factor III (thromboplastin, tissue factor)
 
Chromosomal Location
1p22-p21
 
HGNC ID
 
Summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.(provided by RefSeq, May 2010)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001938 Biological process Positive regulation of endothelial cell proliferation IDA 17898544
GO:0002541 Biological process Activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 Biological process Activation of blood coagulation via clotting cascade IC 17469850
GO:0006919 Biological process Activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17898544
GO:0010641 Biological process Positive regulation of platelet-derived growth factor receptor signaling pathway IDA 17991872
Protein Information
 
Protein Name
Tissue factor
 
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01108 Tissue_fac Tissue factor
PF09294 Interfer-bind Interferon-alpha/beta receptor, fibronectin type III
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Atherothrombosis 22327820
   
References
 
Primary:

Elevated circulating levels of tissue factor in polycystic ovary syndrome.

Gonzalez Frank, Kirwan John P, Rote Neal S, Minium Judi
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gonzalef@iupui.edu
Clin Appl Thromb Hemost. 2013 Jan-Feb;19(1):66-72. doi: 10.1177/1076029612436673.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Plasminogen activator inhibitor 1,DHEA 
Atherothrombosis 
 
 
Related 
 
 In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherothrombosis. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
23900753
Differential expression of inflammation-related genes in the ovarian stroma and granulosa cells of PCOS women. 
In vitro 

 

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