CYR61

Gene Information
 
Gene Symbol
CYR61
 
Aliases
CCN1, GIG1, IGFBP10
 
Entrez Gene ID
 
Gene Name
Cysteine-rich, angiogenic inducer, 61
 
Chromosomal Location
1p22.3
 
HGNC ID
 
Summary
CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.(supplied by OMIM)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0008283 Biological process Cell proliferation TAS 9135077
GO:0009653 Biological process Anatomical structure morphogenesis TAS 9135077
Protein Information
 
Protein Name
Protein CYR61
 
Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00007 Cys_knot Cystine-knot domain
PF00090 TSP_1 Thrombospondin type 1 domain
PF00093 VWC von Willebrand factor type C domain
PF00219 IGFBP Insulin-like growth factor binding protein
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000398736 O00622

Associated Diseases

Diseases References
Aggressiveness (tumor) 15613452
Cancer (carcinoma) 16266990, 18337624, 15526358, 19159527
Endometriosis 16481591, 15044605
Polycystic ovary syndrome (PCOS) 17601910
Preeclampsia 16675545, 20452491, 18089610, 20237132
   
References
 
Primary:

Endometrial expression of Cyr61: a marker of estrogenic activity in normal and abnormal endometrium.

MacLaughlan Shannon D, Palomino Wilder A, Mo Bilan, Lewis Terrence D, Lininger Ruth A, Lessey Bruce A
Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Obstet Gynecol. 2007 Jul;110(1):146-54.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Direct 
59 samples of normal and PCOS endometrium 
Cyr61 is overexpressed in PCOS endometrium, reflecting a heightened responsiveness to estrogen. As a unique marker of estrogen action, Cyr61 may be an early biomarker for the development of hyperplasia or adenocarcinoma in this group of women 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412