CYP3A7

Gene Information
 
Gene Symbol
CYP3A7
 
Aliases
CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA
 
Entrez Gene ID
 
Gene Name
Cytochrome P450, family 3, subfamily A, polypeptide 7
 
Chromosomal Location
7q21-q22.1
 
HGNC ID
 
Summary
This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced. (provided by RefSeq)
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0005789 Cellular component Endoplasmic reticulum membrane EXP 9644715
GO:0019825 Molecular function Oxygen binding EXP 9644715
Protein Information
 
Protein Name
Cytochrome P450 3A7
 
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00067 p450 Cytochrome P450
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000337450

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 18445661
   
References
 
Primary:

Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.

Goodarzi Mark O, Xu Ning, Azziz Ricardo
Department of Obstetrics/Gynecology and Center for Androgen Related Disorders, Cedars-Sinai Medical Center, 8635 West Third Street, Los Angeles, CA 90048, USA.
J Clin Endocrinol Metab. 2008 Jul;93(7):2909-12. Epub 2008 Apr 29.

 

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