CRP

Gene Information
 
Gene Symbol
CRP
 
Aliases
PTX1
 
Entrez Gene ID
 
Gene Name
C-reactive protein, pentraxin-related
 
Chromosomal Location
1q23.2
 
HGNC ID
 
Summary
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006953 Biological process Acute-phase response TAS 2477488
GO:0006954 Biological process Inflammatory response TAS 10408362
GO:0008228 Biological process Opsonization TAS 2477488
GO:0010745 Biological process Negative regulation of macrophage derived foam cell differentiation IDA 18322245
GO:0010888 Biological process Negative regulation of lipid storage IDA 18322245
Protein Information
 
Protein Name
C-reactive protein(1-205)
 
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00354 Pentaxin Pentaxin family
 
OMIM
 
Interactions

Associated Diseases

Diseases References
Acute pancreatitis 11856128, 1713669, 7963355, 12558085, 10752823, 11167871, 15617304, 12850473, 19102837, 12732100, 10877218, 7517087, 17489509, 12483249, 11985972, 8665189, 8055221, 11935133, 1867921, 7749709, 16327837, 10667507, 9058297, 15103565, 1419328, 14685675, 17679375, 12764986, 9577354, 9175217, 8685852, 18415757, 12748420, 10718798, 1709131, 16570356, 14562390, 9700943, 7902182, 19684435, 18416469, 15528022, 14508129, 11280826, 10644318, 9026481, 15202793, 12856185, 11972545, 16498235, 11176162, 9382059, 8119637, 8807361, 16161922, 11577303, 9918438, 18849642, 20130823, 9825062
Appendicitis 19070557, 17618882, 19878592, 19855981, 16715420, 1941740, 15995845, 15448768, 8592927, 15117047, 17502181, 19102827, 16483301, 17132173, 19562239, 8831071, 16759345, 14688403, 10706923, 17453494, 12893500, 1455149, 17462226, 15631364, 12578424, 20128109, 15653442, 7497838, 18700623, 19672084, 8070088, 9076439, 15784220, 10340286, 10552288, 11440098, 10215824, 10934841, 17462226, 15653442, 16032609, 15943411, 8098625, 10967943, 16483301, 1455149, 7497838, 10815376, 7886405, 1393485, 19102827, 16782436, 9279962, 19878592, 8070088, 9656532, 18700623, 19568576, 9271034, 15783013, 17365999, 11705213, 17101603, 15117047, 10452263, 14534661, 18435206
Arthritis 19109734, 10439120, 10648018, 16095115, 19327240, 16513489, 1444626, 9797570, 12910965, 19533138, 11005786, 16519113, 18848489, 19060001, 12673896, 10690660, 9310104, 8882022, 8076397, 17405296, 10225388, 8539715, 1704698, 17925630, 16331755, 16159950, 15628048, 14644865, 12827405, 10885836, 7709183, 8023590, 7699628, 20067641, 16770519, 14626627, 10342023, 2117410, 19663194, 17879732, 18578976, 17417996, 15266537, 15209962, 15142266, 12687288, 9694059, 20143006, 8019793, 15338451, 15633936, 12014256, 17075277, 16881360, 16432687, 14969053, 18827961, 17888212, 11729668, 1752286, 15801028, 15972357, 19032813, 16489709, 8539481, 17516213, 20433772, 10986307, 2322779, 19263661, 7748016, 1810225, 9182920, 11579710, 18446013, 18983663, 16146609, 7562749, 12934959, 12635783, 11496741, 11171691, 11005786, 9802936, 1539125, 1752286, 20346233, 17029089, 12942698, 12942694, 12419286, 11817593, 11928230, 9263138, 1563753, 2065506, 15726373, 15940764, 14969053, 12810437, 11805935, 12768666, 11019525, 10990219, 10439120, 17159015, 15708880, 11426029, 8747080, 7664026, 2302265, 8102225, 19095696, 18490431, 8473487, 20156948, 7575694, 19630828, 19606218, 18803034, 18071707, 16926186, 11750284, 7775894, 8299257, 11064595, 9002004, 8744678, 7529838, 8517038, 20436910, 20108506, 17040961, 15124246, 15039493, 14500038, 10515645, 7839158, 1384103, 1805325, 2353152, 9789970, 9002006, 8336307, 1486740, 1720888, 1979349, 18759279, 16079166, 1704698, 19962617, 18372435, 17261875, 15932751, 15958758, 15485995, 15048997, 19531760, 19411389, 19032813, 16295525, 12476931, 18503600, 2059079, 15260390, 17179176, 16513489, 1522987, 8853166, 14648981, 12162154, 18078633, 2023183, 19851514, 9105165, 10028869, 11848326, 11890655, 10910610, 16052597, 15727922, 1704698, 19017467, 17353582, 18055473, 7586981, 19032813, 18672001, 7562749, 10439120, 9263139, 17657447, 17157039, 16688934, 19682376, 17395501, 18973027, 15897314, 18196391, 17672071, 10894836, 11005786, 11277348, 11922199, 12479380, 16485108, 7562749, 1384103, 19762363, 8624640, 16513489, 12724603, 10541950, 10225388, 11218681, 12608977, 15105739, 18578968
Arthropathy 1575582, 1704698, 12810432, 10986307, 17067658, 16688934, 9972954, 11727841, 7848311, 15308517
Atherosclerosis 12468765, 17576871, 11448405, 16526209, 14744975, 12887727, 15919817, 18535598, 17261875, 11256974, 16140307, 19415283, 15306744, 20436910, 18714381, 16624260, 18293141, 15631881, 14514239, 19060627, 15920036, 15323255, 17004092, 19323703, 18957790, 19055599, 15701058, 20134100, 17613401, 17584094, 15704532, 19463117, 17588586, 17342636, 17349013, 16032519, 12171795, 15277326, 15047680, 19695857, 19076828, 18551710, 16580524, 16290959, 16087797, 12933535, 17196470, 15550763, 16557022, 16489253, 16078603, 15635110, 15586013, 12494114, 18327405, 18313449, 17169243, 16455016, 16456095, 15802624, 17714718, 16876827, 16803998, 15954911, 12006399, 19276989, 19459559, 18254451, 17060895, 16936085, 15996055, 15354978, 10721674, 11472751, 11739438, 12026529, 11937016, 12006917, 12351483, 12615790, 15991565, 15902817, 15467191, 15378141, 15285415, 15201235, 15012690, 12801614, 12694312, 18539932, 18361073, 17350021, 18163969, 16510273, 17719297, 17598653, 17356342, 17351374, 16191077, 17939261, 16443738, 20034371, 15378109, 10994751, 11980679, 19695857, 16022949, 12102655, 12756677, 16102622, 16874696, 20134100, 12564292, 20382347, 11305531, 18784881, 18686755, 17258821, 16151032, 15787300, 11238052, 18508060, 16601222, 15130417, 20091096, 19027598, 15513325, 17531242, 17893410, 15939068, 14566035, 18714381, 16244112, 16624260, 16580524, 19074520, 16996873, 16337036, 16126025, 10462018, 12900819, 15576654, 16242528, 16917108, 18245817, 19617288, 17576871, 17082472, 17068002, 19428053, 18289549, 17196470, 15155971, 12377746, 18640377, 12900819, 16908949, 17045118, 18049109, 18091698, 11742871, 19755760, 19060627, 15171748, 16319544, 15944720, 17382553, 10994751, 16123322, 17344325, 18317426, 16737083, 16975572, 16096932, 7832094, 16161944, 10769278, 12756677, 15119695, 16517503, 20134100, 10521364, 11871134, 17441409, 16466728, 16146596, 20131929, 12625599, 15710760, 15761966, 18690412, 17696927, 18804762, 17270293, 16405895, 16911184, 12208790, 12933535, 16675048, 19476113, 19681467, 10488966, 14557360, 15289378, 17306806, 15519013
   
References
 
Primary:

Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance.

Bahceci Mithat, Tuzcu Alpaslan, Canoruc Naime, Tuzun Yekta, Kidir Veysel, Aslan Cetin
Department of Endocrinology, Dicle University School of Medicine, Diyarbakir, Turkey. mbahceci@dicle.edu.tr
Horm Res. 2004;62(6):283-7. Epub 2004 Nov 9.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
cardiovascular risk 
 
Rotterdam criteria 
Related 
30 PCOS, 30 PCO and 30 controls 
women with PCO have higher serum CRP levels than healthy control women. This may contribute to increased cardiovascular disease risk in patients with PCO 
 
BMI, PCOS 
 
 
Related 
40 PCOS and 30 controls  
In patients with PCOS, serum CRP levels were higher than age and BMI-matched controls 
MCP-1 
 
 
 
Related 
85 PCOS and 65 Control 
Patients with PCOS suffer low-grade chronic inflammation indicated by higher levels of CRP and MCP-1, which could lead to increased risk of atherogenesis 
PTX3 
 
 
 
Related 
40 PCOS and 40 controls 
PTX3 level is increased in patients with PCOS in concordance with insulin resistance. 
PEDF  
 
 
 
Related 
96 PCOS and 63controls 
The serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26340353
The relationship between epicardial adipose tissue thickness and oxidative stress parameters in patients with isolated polycystic ovary syndrome. 
Clinical study 
26330853, PMC4555058
Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome. 
Clinical study 
26315303
Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. 
Effect of treatment 
26295295
Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome. 
Clinical study 
26292090, PMC4548699
Levels of Neopterin and other Inflammatory Markers in Obese and Non-Obese Patients with Polycystic Ovary Syndrome. 
Clinical study 

 

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