CRH

Gene Information
 
Gene Symbol
CRH
 
Aliases
CRF1, CRH
 
Entrez Gene ID
 
Gene Name
Corticotropin releasing hormone
 
Chromosomal Location
8q13
 
HGNC ID
 
Summary
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 7867564
GO:0007268 Biological process Synaptic transmission TAS 7477348
GO:0007565 Biological process Female pregnancy TAS 7585095
GO:0007567 Biological process Parturition TAS 7585095
GO:0007611 Biological process Learning or memory TAS 7477348
Protein Information
 
Protein Name
Corticotropin releasing hormone
 
Function
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00473 CRF Corticotropin-releasing factor family
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000276571 P06850

Associated Diseases

Diseases References
Acth deficiency 8882784, 1660365, 1313844, 9152624, 11341487
Alcoholism 17629579, 15582675, 18164903, 1336204, 7978091, 16639867, 11371718, 15203442, 19913192, 12605072, 18583480, 1975969
Alzheimers disease 11442356, 7653697, 7477348, 9109532, 8132871, 2173839, 1682848, 9358882, 12476966, 20472147, 16181081, 10565497, 8704061, 10802523, 10565496, 2171685, 8547442, 16046283, 15996533, 17351315, 10628754, 1359604
Anorexia nervosa 7864577, 8911861, 1547737, 1336204, 8169565, 17076196, 16455105, 17127316, 8961238, 1597149, 11940052, 8232766
Anxiety disorders 16594259, 8491091, 9854171, 10599479, 8731457, 16870185, 15573019, 14698679, 10918705, 14575894, 16884458, 12845406, 11337099, 8643680, 18384079, 17065965, 15331578, 12769601, 10867111, 20010888, 18622363, 15509759, 15240401, 19520785, 18412102, 15212620, 11282691, 19738931, 15278013, 15214502, 14563384, 17287823, 16769145, 12662131, 17044726, 1361969, 8018584, 15523186, 19120089, 15338958, 18801728, 18397172, 15974983, 15538210, 10599478, 18292205
   
References
 
Primary:
PMID: 8986680

Somatostatin treatment reduces the exaggerated response of adrenocorticotropin hormone and cortisol to corticotropin-releasing hormone in polycystic ovary syndrome.

Lanzone A, Fulghesu A M, Guido M, Cucinelli F, Caruso A, Mancuso S
Oasi Institute of Research, Troina, Italy.
Fertil Steril. 1997 Jan;67(1):34-9.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ACTH 
 
 
 
Related 
 
This study supports the hypothesis that the adrenal gland in patients with PCO produces increased amounts of androstenedione in response to ACTH stimulation. 
ACTH  
 
 
 
Related 
12 women aged 17 to 32 years having PCOS and 15control 
The results are consistent with the hypothesis that women with PCOS may demonstrate hyperfunction of the hypothalamic-pituitary-adrenal axis, which may be involved in the physiopathologic events leading to the complexity of the syndrome. 

 

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