CPB2

Gene Information
 
Gene Symbol
CPB2
 
Aliases
CPU, PCPB, TAFI
 
Entrez Gene ID
 
Gene Name
Carboxypeptidase B2 (plasma)
 
Chromosomal Location
13q14.11
 
HGNC ID
 
Summary
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jun 2013)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006508 Biological process Proteolysis TAS 10651877
Protein Information
 
Protein Name
Carboxypeptidase B2
 
Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00246 Peptidase_M14 Zinc carboxypeptidase
PF02244 Propep_M14 Carboxypeptidase activation peptide
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Cardiovascular diseases 19368913, 18958767
Insulin resistance 19368913
Obesity 19368913
Polycystic ovary syndrome (PCOS) 19253106
   
References
 
Primary:

Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome.

Adali Ertan, Yildizhan Recep, Kurdoglu Mertihan, Bugdayci Guler, Kolusari Ali, Sahin H Guler
Department of Obstetrics and Gynecology, Yuzuncu Yil University, Van, Turkey. ertanadali@gmail.com
Fertil Steril. 2010 Jul;94(2):666-72. doi: 10.1016/j.fertnstert.2009.03.037. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Cardiovascular diseases 
 
 
Related 
 
 
Lipoproteins,(PAI-1,fibrinogen concentration, thrombomodulin, thrombin-antithrombin (TAT) complexes,Antithrombin III (AT III) and activated protein C  
 
 
 
Related 
 
This study showed that plasma levels of TAFI, PAI-1, D-dimer, AT III and thrombomodulin were significantly increased in women with PCOS compared with age- and BMI-matched controls. 
DHEAS,E(2) 
Obesity,cardiovascular diseases and insulin resistance 
 
Rotterdam criteria 
Related 
 
Young overweight or obese women with PCOS have increased plasma thrombin-activatable fibrinolysis inhibitor levels 

 

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