COMT

Gene Information
 
Gene Symbol
COMT
 
Aliases
HEL-S-98n
 
Entrez Gene ID
 
Gene Name
Catechol-O-methyltransferase
 
Chromosomal Location
22q11.21
 
HGNC ID
 
Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. (provided by RefSeq)
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0005792 Cellular component Microsome TAS 1707278
GO:0005829 Cellular component Cytosol EXP 8968737
GO:0043231 Cellular component Intracellular membrane-bounded organelle IDA 18029348
GO:0005515 Molecular function Protein binding IPI 15231747
GO:0008171 Molecular function O-methyltransferase activity TAS 1707278
Protein Information
 
Protein Name
Catechol O-methyltransferase
 
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR017128, IPR002935
 
Pfam
Pfam Accession Pfam ID
PF01596 Methyltransf_3 O-methyltransferase
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions

Associated Diseases

Diseases References
Aggressive behavior 15817751, 15211623, 18163386, 12815735, 9619160, 18075475, 10581481
Alcoholism 10898913, 16648777, 10395222, 17850222, 16499480, 11244495, 19023276, 17079080, 12741370, 10698363, 17347351, 18181582, 12741370, 10686561
Alzheimers disease 16257094, 16698101, 15852364, 15488308, 16582043, 19793392
Anorexia nervosa 18574484, 11317231, 16118784, 17028449, 14681918
Antisocial behavior 10898913, 19997043, 17075359, 18250258
   
References
 
Primary:

Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome.

Salih Sana, Xu Xia, Veenstra Timothy D, Duleba Antoni J, Fouad Hala, Nagamani Manubai, Al-Hendy Ayman
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0587, USA.
J Clin Endocrinol Metab. 2007 Aug;92(8):3285-91. Epub 2007 May 29.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
24287819
Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology. 
In vitro 
22234472
Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells. 
In vitro 
22178088, PMC3264817
Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome. 
Clinical study 

 

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