CHI3L1

Gene Information
 
Gene Symbol
CHI3L1
 
Aliases
ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39
 
Entrez Gene ID
 
Gene Name
Chitinase 3-like 1 (cartilage glycoprotein-39)
 
Chromosomal Location
1q32.1
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006954 Biological process Inflammatory response IEP 16234240
GO:0030324 Biological process Lung development IMP 18403759
GO:0034612 Biological process Response to tumor necrosis factor IEP 16234240
GO:0051216 Biological process Cartilage development NAS 8245017
GO:0070555 Biological process Response to interleukin-1 IEP 16234240
Protein Information
 
Protein Name
Chitinase-3-like protein 1
 
Function
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00704 Glyco_hydro_18 Glycosyl hydrolases family 18
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Abnormal glucose tolerance 22583189
   
References
 
Primary:

Elevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome.

Celik Cem, Abali Remzi, Guzel Savas, Bastu Ercan, Kucukyalcin Volkan, Yilmaz Murat
Department of Gynecology and Obstetrics, Namik Kemal University, Turkey. ccelik@nku.edu.tr
Clin Endocrinol (Oxf). 2012 Dec;77(6):893-7. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Glucose tolerance 
 
 
Related 
Turkey- 85 PCOS with normal glucose tolerance and 25 PCOS with abnormal glucose tolerance and 59 controls 
Plasma YKL-40 levels increased in patients with PCOS compared to healthy subjects. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
24471491
Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40. 
Clinical sudy 

 

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