CHGA

Gene Information
 
Gene Symbol
CHGA
 
Aliases
CGA
 
Entrez Gene ID
 
Gene Name
Chromogranin A (parathyroid secretory protein 1)
 
Chromosomal Location
14q32
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0008217 Biological process Regulation of blood pressure TAS 8406464
Protein Information
 
Protein Name
ER-37
 
Function
Pancreastatin strongly inhibits glucose induced insulin release from the pancreas
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01271 Granin Granin (chromogranin or secretogranin)
 
OMIM

Associated Diseases

Diseases References
Hypoglycaemia 9135698
   
References
 
Primary:
PMID: 9135698

The counterregulatory response to hypoglycaemia in women with the polycystic ovary syndrome.

Gennarelli G, Holte J, Stridsberg M, Niklasson F, Berne C, Backstrom T
Department of Obstetrics and Gynaecology, Akademiska Hospital, Uppsala University, Sweden.
Clin Endocrinol (Oxf). 1997 Feb;46(2):167-74.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Hypoglycaemia 
 
 
Related 
 
The obese women with PCOS exhibited blunted responses of noradrenaline and NPY, but similar increases of adrenaline and CGA, compared with the obese controls. 

 

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