CGB5

Gene Information
 
Gene Symbol
CGB5
 
Aliases
CGB, HCG, hCGB
 
Entrez Gene ID
 
Gene Name
Chorionic gonadotropin, beta polypeptide 5
 
Chromosomal Location
19q13.32
 
HGNC ID
 
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
Protein
Protein Information
 
Protein Name
CGB3 , CG-beta , chorionic gonadotropin beta 5 subunit , chorionic gonadotropin, beta polypeptide 5 , HCG , Chorionic gonadotrophin chain beta
 
Function
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
 
UniProt
 
InterPro
 
OMIM
608825

Associated Diseases

Show/Hide all(3)
Diseases References
Hyperandrogenemic 19240152
Oligoamenorrheic 19240152
Polycystic ovary syndrome (PCOS) 19240152
   
References
 
Primary:

Characterization of functionally typical and atypical types of polycystic ovary syndrome.

Hirshfeld-Cytron Jennifer, Barnes Randall B, Ehrmann David A, Caruso Anthony, Mortensen Monica M, Rosenfield Robert L
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
J Clin Endocrinol Metab. 2009 May;94(5):1587-94. doi: 10.1210/jc.2008-2248. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
FSH 
PCOS, oligoamenorrheic, hyperandrogenemic 
 
NIH criteria 
Related 
30 typical PCOS cohort, 14 atypical PCOS cohort, 14 Controls (non hispanic whites and blacks) 
Typical PCOS is characterized by intrinsic ovarian hypersensitivity to hCG to which excessive paracrine FSH signaling via inhibin-B may contribute. Atypical PCOS is due to a unique type of ovarian dysfunction that is relatively gonadotropin hyposensitive. 

Unreviewed Literature:

Show/Hide all(1)
PubMed / PMC ID
Title Type of study
24680396
A comparison of the miscarriage rate between women with and without polycystic ovarian syndrome undergoing IVF treatment. 
Clinical sudy 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412