CDX2

Gene Information
 
Gene Symbol
CDX2
 
Aliases
CDX-3/AS, CDX3, CDX2
 
Entrez Gene ID
 
Gene Name
Caudal type homeobox 2
 
Chromosomal Location
13q12.2
 
HGNC ID
 
Summary
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 (PubMed 7698771)).(supplied by OMIM)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006355 Biological process Regulation of transcription, DNA-dependent TAS 9459001
GO:0006366 Biological process Transcription from RNA polymerase II promoter TAS 9459001
GO:0009887 Biological process Organ morphogenesis TAS 9052785
Protein Information
 
Protein Name
Homeobox protein CDX-2
 
Function
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00046 Homeobox Homeobox domain
PF04731 Caudal_act Caudal like protein activation region
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000370408 Q99626

Associated Diseases

Diseases References
Amenorrhea 21271150
Ascites 16541450
Cancer (carcinoma) 14668551, 18992917, 16191504, 15205684, 17906616, 16996572, 17206949, 19725873, 19820687, 17906616, 16291394, 16677504, 17342306, 20198783, 18581275, 18843504, 19221108
Cysts 19523243
Inflammation 19251954, 20132083, 19564133
   
References
 
Primary:

Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome.

Wehr Elisabeth, Trummer Olivia, Giuliani Albrecht, Gruber Hans-Jurgen, Pieber Thomas R, Obermayer-Pietsch Barbara
Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. elisabeth.wehr@medunigraz.at
Eur J Endocrinol. 2011 May;164(5):741-9. Epub 2011 Mar 9.

 

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