CD36

Gene Information
 
Gene Symbol
CD36
 
Aliases
BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
 
Entrez Gene ID
948
 
Gene Name
CD36 molecule (thrombospondin receptor)
 
Chromosomal Location
7q11.2
 
HGNC ID
 
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001954 Biological process Positive regulation of cell-matrix adhesion IDA 17416590
GO:0006629 Biological process Lipid metabolic process NAS 7518447
GO:0007263 Biological process Nitric oxide mediated signal transduction IDA 17416590
GO:0010744 Biological process Positive regulation of macrophage derived foam cell differentiation IMP 10772654
GO:0015911 Biological process Plasma membrane long-chain fatty acid transport IDA 17416590
Protein Information
 
Protein Name
CHDS7 , fatty acid translocase , cluster determinant 36 , platelet glycoprotein 4 , CD36 antigen (collagen type I receptor, thrombospondin receptor) , FAT , scavenger receptor class B, member 3 , OTTHUMP00000207879 , PASIV , PAS IV , OTTHUMP00000229733 , Leukocyte differentiation antigen CD36 , GPIV , GP3B , SCARB3 , platelet glycoprotein IV , GPIIIB , Thrombospondin receptor , PAS-4 , CD36 antigen , OTTHUMP00000207872 , PAS-4 protein , OTTHUMP00000207874 , Platelet collagen receptor , Fatty acid translocase , OTTHUMP00000207881 , OTTHUMP00000207938 , Glycoprotein IIIb , CD36 molecule (thrombospondin receptor), glycoprotein IIIb , Platelet glycoprotein IV , GP4 , leukocyte differentiation antigen CD36
 
Function
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR005428, IPR002159
 
Pfam
Pfam Accession Pfam ID
PF01130 CD36 CD36 family
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000308165 P16671

Associated Diseases

Diseases References
Atherosclerosis 12569165, 14720468, 17673938, 16552394, 10323787, 16869454, 19931584, 8178945
Cancer (pancreatic cancer) 18224679, 16622460, 15534120, 17178870
Hypertrophy 19342682, 15119700, 15647776, 8958302
Inflammation 18782014, 9526920, 19864601, 19118379
Polycystic ovary syndrome (PCOS) 15498184, 19423542
   
References
 
Primary:

[Correlation between local hormones and CD36 transcription level in women with polycystic ovary].

Yao Liang-qing, Kuang Jian-quan, Yang Dong-zi, Li Lin, He Ying-ming, Li Guang-yi, Chen Lu-shi
Department Obstetrics and Gynecology, Affiliated Second Hospital, Zhongshan University, Guangzhou 510120, China.
Zhonghua Fu Chan Ke Za Zhi. 2004 Sep;39(9):591-4.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Direct 
12 women with asymmetric PCO, 15 primary/ secondary infertile women without endocrine disorders and 8 polycystic ovary syndrome (PCOS) with bilateral PCO 
Decrease in CD(36) mRNA may play a role in the pathogenesis of PCO by increasing the level of T and INS in follicular fluid 
HSL and ATGL 
 
 
Rotterdam criteria 
Related 
10 women with PCOS,10 healthy controls 
The results of this study suggest that in insulin-resistant women with PCOS, changes in CD36 and HSL expression may result in altered FFA uptake.  

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25702158
Cardiac fatty acid uptake and metabolism in the rat model of polycystic ovary syndrome. 
Animal study 

 

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