CCL2

Gene Information
 
Gene Symbol
CCL2
 
Aliases
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
 
Entrez Gene ID
 
Gene Name
Chemokine (C-C motif) ligand 2
 
Chromosomal Location
17q11.2-q21.1
 
HGNC ID
 
Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (provided by RefSeq, Jul 2013)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001525 Biological process Angiogenesis TAS 18334747
GO:0002548 Biological process Monocyte chemotaxis IDA 12207323
GO:0006468 Biological process Protein phosphorylation TAS 9670957
GO:0006916 Biological process Anti-apoptosis IDA 12753088
GO:0006959 Biological process Humoral immune response TAS 9548499
Protein Information
 
Protein Name
C-C motif chemokine 2
 
Function
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR000827, IPR001811
 
Pfam
Pfam Accession Pfam ID
PF00048 IL8 Small cytokines (intecrine/chemokine), interleukin-8 like
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Atherogenesis 21530057, 19375763
Chronic low-level inflammation 19375763
Hyperandrogenism 19375763
Hyperglycemia 19375763
Hyperinsulinism 17565837
   
References
 
Primary:

Elevated C-reactive protein and monocyte chemoattractant protein-1 in patients with polycystic ovary syndrome.

Hu Weihong, Qiao Jie, Yang Yan, Wang Lina, Li Rong
Department of Gynaecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China.
Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):53-6. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
C-reactive protein 
Vascular damage and cardiovascular disease 
 
 Rotterdam criteria 
Related 
 
Serum monocyte chemoattractant protein-1 levels were positively correlated with serum LH, T, and C-reactive protein levels. 
IL-6,MMP2,sICAM-1,CRP,PAI-1 
Chronic low-level inflammation,atherogenesis,hyperandrogenism,hyperglycemia, 
 
 Rotterdam criteria 
Related 
 
The study concludes that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis. 
Prolactin 
Obesity, hyperinsulinemia, and insulin resistance 
 
 
Related 
 
The serum level of MCP-1 is associated with the LH level in POCS patients. 
Apo A,ApoB, LP(a),PRL,E2 
 
 
 
Related 
 
PCOS obese and non-obese patients had higher serum MCP-1 levels than controls. 
MIP-1alpha and MIF 
 
 
 
Related 
 
Hirsute patients had significantly increased MCP-1 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25343339, PMC4208840
The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome. 
Animal study 
25068085, PMC4110095
Gene expression in subcutaneous adipose tissue differs in women with polycystic ovary syndrome and controls matched pair-wise for age, body weight, and body mass index. 
Clinical study 
24906976
Adiponectin, interleukin-6, monocyte chemoattractant protein-1, and regional fat mass during 12-month randomized treatment with metformin and/or oral contraceptives in polycystic ovary syndrome. 
Effect of treatment 
23900753
Differential expression of inflammation-related genes in the ovarian stroma and granulosa cells of PCOS women. 
In vitro 
23824412, PMC3763978
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. 
In vitro 

 

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