CCK

Gene Information
 
Gene Symbol
CCK
 
Entrez Gene ID
885
 
Gene Name
Cholecystokinin
 
Chromosomal Location
3p22.1
 
HGNC ID
 
Summary
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001764 Biological process Neuron migration ISS 15152034
GO:0007165 Biological process Signal transduction TAS 10320330
GO:0007409 Biological process Axonogenesis ISS 15152034
GO:0042755 Biological process Eating behavior ISS 15374756
GO:0030424 Cellular component Axon ISS 15152034
Protein Information
 
Protein Name
Cholecystokinin-5
 
Function
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00918 Gastrin Gastrin/cholecystokinin family
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000335657 P06307

Associated Diseases

Diseases References
Alzheimers disease 7540926, 1674117, 8872869
Anorexia nervosa 1796180, 15645696, 8771219, 9129788
Anxiety disorders 7948449, 19327970, 9811424, 11713976
Apeced 11172154, 11439954, 11439955
Celiac disease 10406250, 9539666, 16954951, 18372593
   
References
 
Primary:

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome.

Hirschberg A Linden, Naessen S, Stridsberg M, Bystrom B, Holtet J
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden. Angelica.Hirschberg@ks.se
Gynecol Endocrinol. 2004 Aug;19(2):79-87.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
24001751
Basal and meal-stimulated ghrelin, PYY, CCK levels and satiety in lean women with polycystic ovary syndrome: effect of low-dose oral contraceptive. 
Effect of treatment 
21913952
Improved gall bladder motility in PCOS women treated with metformin--interaction of free fatty acids with circulating cholecystokinin? 
Effect of treatment 

 

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