CALCA

Gene Information
 
Gene Symbol
CALCA
 
Aliases
CT, KC, CGRP, CALC1, CGRP1, CGRP-I
 
Entrez Gene ID
796
 
Gene Name
Calcitonin-related polypeptide alpha
 
Chromosomal Location
11p15.2
 
HGNC ID
 
Summary
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Nov 2009)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein
Protein Information
 
Protein Name
Katacalcin, Calcitonin gene-related peptide 1
 
Function
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP| Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones| Katacalcin is a potent plasma calcium-lowering peptide
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00214 Calc_CGRP_IAPP Calcitonin / CGRP / IAPP family
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 10923281, 17603492, 10207720, 9222646, 15855352, 17235527, 15331560, 15657373, 18812636, 22314079, 23685425, 22621829, 20504873, 21270326, 19240152, 17445806
   
References
 
Primary:

Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction.

Pepene Carmen Emanuela
Department of Endocrinology, University of Medicine and Pharmacy Cluj-Napoca, Romania. c_e_georgescu@yahoo.com
Gynecol Endocrinol. 2012 May;28(5):370-4. doi: 10.3109/09513590.2011.632792. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
E(2) 
 
 
 
Related 
 
The present findings suggest that CGRP may participate in the pathophysiological process of PCOS. 

 

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