C3

Gene Information
 
Gene Symbol
C3
 
Aliases
AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p, C3
 
Entrez Gene ID
718
 
Gene Name
Complement component 3
 
Chromosomal Location
19p13.3-p13.2
 
HGNC ID
 
Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006955 Biological process Immune response TAS 4097977
GO:0006957 Biological process Complement activation, alternative pathway EXP 162484
GO:0007165 Biological process Signal transduction TAS 10085065
GO:0007186 Biological process G-protein coupled receptor protein signaling pathway TAS 9164946
GO:0010575 Biological process Positive regulation vascular endothelial growth factor production IDA 16452172
Protein Information
 
Protein Name
Complement component 3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 , complement C3 , ASP , ARMD9 , complement component C3 , CPAMD1 , AHUS5 , OTTHUMP00000197086 , acylation-stimulating protein cleavage product
 
Function
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates| Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00207 A2M Alpha-2-macroglobulin family
PF01759 NTR UNC-6/NTR/C345C module
PF01821 ANATO Anaphylotoxin-like domain
PF01835 A2M_N MG2 domain
PF07677 A2M_recep A-macroglobulin receptor
PF07678 A2M_comp A-macroglobulin complement component
PF07703 A2M_N_2 Alpha-2-macroglobulin family N-terminal region
PF10569 Thiol-ester_cl Alpha-macro-globulin thiol-ester bond-forming region
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000245907 P01024

Associated Diseases

Diseases References
Arthritis 2111124
Atherosclerosis 19687018
Diabetes mellitus 7835212
Hemolysis 7919596
Inflammation 11037838, 1511195, 9051331, 16982879
   
References
 
Primary:

Serum complement C3 has a stronger association with insulin resistance than high-sensitivity C-reactive protein in women with polycystic ovary syndrome.

Yang Shumin, Li Qifu, Song Ying, Tian Bo, Cheng Qingfeng, Qing Hua, Zhong Li, Xia Wei
Department of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Fertil Steril. 2011 Apr;95(5):1749-53. Epub 2011 Feb 12.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
24592986, PMC4065194
Complement protein C3 and coronary artery calcium in middle-aged women with polycystic ovary syndrome and controls. 
Clinical study 
24551574, PMC3911815
Assessment of C-reactive Protein and C3 as Inflammatory Markers of Insulin Resistance in Women with Polycystic Ovary Syndrome: A Case-Control Study. 
Clinical study 

 

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