BMP15

Gene Information
 
Gene Symbol
BMP15
 
Aliases
GDF9B, ODG2, POF4
 
Entrez Gene ID
 
Gene Name
Bone morphogenetic protein 15
 
Chromosomal Location
Xp11.2
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007292 Biological process Female gamete generation TAS 9849956
Protein Information
 
Protein Name
Bone morphogenetic protein 15
 
Function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00019 TGF_beta Transforming growth factor beta like domain
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Infertility 10888873, 15836954, 18308851
Ovarian dysgenesis 15836954
Polycystic ovary syndrome (PCOS) 22014425, 25172094
   
References
 
Primary:

Mutational analysis of human bone morphogenetic protein 15 in Chinese women with polycystic ovary syndrome.

Liu Jingjing, Wang Binbin, Wei Zhaolian, Zhou Ping, Zu Yuping, Zhou Sirui, Wen Qiaolian, Wang Jing, Cao Yunxia, Ma Xu
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Metabolism. 2011 Nov;60(11):1511-4.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
c.34C>G, c.109G>C, c.169C>G, c.288G>C, and c.598C>T 
NIH criteria 
Direct 
216 Chinese PCOS patients 
These results are the first to indicate that BMP15 gene mutations may be potentially associated with PCOS patients 
GDF9 
 
 
 
Direct 
28 women with PCOS, 26 controls 
The expression of these proteins is reduced and delayed in the early follicular stage in PCOS ovarian tissues, and these differences in expression may be associated with aberrant follicular development in patients with PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
24391762, PMC3877038
Effects of upregulation of Hsp27 expression on oocyte development and maturation derived from polycystic ovary syndrome. 
In vitro 
23912750, PMC3824850
Inhibitory effects of controlled ovarian stimulation on the expression of GDF9 and BMP15 in oocytes from women with PCOS. 
Clinical study 
23302121
[Change and significance of growth differentiation factor 9 and bone morphogenetic protein expression during oocyte maturation in polycystic ovary syndrome patients with ovarian stimulation]. 
Clinical study 
22825968, PMC3492567
Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation. 
In vitro 
21669410
Abnormal expression of growth differentiation factor 9 and bone morphogenetic protein 15 in stimulated oocytes during maturation from women with polycystic ovary syndrome. 
Clinical study 

 

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