BDNF

Gene Information
 
Gene Symbol
BDNF
 
Aliases
ANON2, BULN2
 
Entrez Gene ID
627
 
Gene Name
Brain-derived neurotrophic factor
 
Chromosomal Location
11p14.1
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007399 Biological process Nervous system development TAS 2236018
GO:0005515 Molecular function Protein binding IPI 7703225
Protein Information
 
Protein Name
OTTHUMP00000232043 , OTTHUMP00000232022 , MGC34632 , abrineurin , brain-derived neurotrophic factor, OTTHUMP00000232013 , OTTHUMP00000232020 , OTTHUMP00000232015 , OTTHUMP00000232039 , OTTHUMP00000232014 , neurotrophin , OTTHUMP00000232040 , OTTHUMP00000232021 , OTTHUMP00000232005 , Abrineurin , OTTHUMP00000232016 , OTTHUMP00000232018 , OTTHUMP00000232019 , OTTHUMP00000232006 , OTTHUMP00000232041
 
Function
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00243 NGF Nerve growth factor family
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000414303 P23560

Associated Diseases

Diseases References
Allergic reaction 17584309
Alzheimers disease 12456067, 12654514, 12358753, 16362629
Amyotrophic lateral sclerosis 15094483, 9737545, 11211839, 16878402
Anorexia nervosa 19568484, 18363853, 12915293, 15997610
Anxiety disorders 15374669, 18602452, 18603005, 20075215
   
References
 
Primary:

Polycystic ovary syndrome: brain-derived neurotrophic factor (BDNF) plasma and follicular fluid levels.

Russo N, Russo M, Daino D, Bucci F, Pluchino N, Casarosa E, Artini P G, Cela V, Luisi M, Genazzani A R
Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy. nataliarusso@libero.it
Gynecol Endocrinol. 2012 Apr;28(4):241-4.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26108912
Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome. 
Animal study 
24498077, PMC3909077
BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study. 
Clinical study 
22420627
Polycystic ovary syndrome: brain-derived neurotrophic factor (BDNF) plasma and follicular fluid levels. 
Clinical study 

 

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