AQP9: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

AQP9

Aliases

AQP-9, HsT17287, SSC1

Entrez Gene ID

366

Gene Name

Aquaporin 9

Chromosomal Location

15q

HGNC ID

643

Summary

The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. (provided by RefSeq)

GeneCards ID

GC15P058430

UniGene

Hs.104624

RefSeq DNA

NC_000015.9, NT_010194.17

RefSeq mRNA

NM_020980.3

e!Ensembl

Gene	ENSG00000103569
Transcript	ENST00000558772, ENST00000219919, ENST00000559443, ENST00000536493
Protein	ENSP00000219919, ENSP00000441390

Gene Ontology (GO)

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GO ID	Ontology	Definition	Evidence	Reference
GO:0006810	Biological process	Transport	TAS	9733774
GO:0006863	Biological process	Purine base transport	IDA	9733774
GO:0006955	Biological process	Immune response	TAS	9514918
GO:0006970	Biological process	Response to osmotic stress	TAS	9733774
GO:0007588	Biological process	Excretion	TAS	9733774
GO:0008152	Biological process	Metabolic process	TAS	9733774
GO:0010033	Biological process	Response to organic substance	IDA	9733774
GO:0015791	Biological process	Polyol transport	IDA	9733774
GO:0015837	Biological process	Amine transport	TAS	9733774
GO:0015855	Biological process	Pyrimidine base transport	IDA	9733774
GO:0030104	Biological process	Water homeostasis	NAS	9733774
GO:0046689	Biological process	Response to mercury ion	IDA	9733774
GO:0046942	Biological process	Carboxylic acid transport	TAS	9733774
GO:0071320	Biological process	Cellular response to cAMP	IEP	17636236
GO:0005887	Cellular component	Integral to plasma membrane	TAS	9514918
GO:0016021	Cellular component	Integral to membrane	NAS	9733774
GO:0043231	Cellular component	Intracellular membrane-bounded organelle	IDA	18718702
GO:0005275	Molecular function	Amine transmembrane transporter activity	TAS	9733774
GO:0005345	Molecular function	Purine base transmembrane transporter activity	IDA	9733774
GO:0005350	Molecular function	Pyrimidine base transmembrane transporter activity	IDA	9733774
GO:0005372	Molecular function	Water transmembrane transporter activity	TAS	9733774
GO:0015166	Molecular function	Polyol transmembrane transporter activity	TAS	9733774
GO:0015250	Molecular function	Water channel activity	IDA	9733774
GO:0015288	Molecular function	Porin activity	NAS	9733774
GO:0046943	Molecular function	Carboxylic acid transmembrane transporter activity	TAS	9733774

Protein Information

Protein Name

Aquaporin-9

Function

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol

Refseq Proteins

NP_066190.2

UniProt

O43315

InterPro

Accessions

IPR023271, IPR000425, IPR022357, IPR012269, IPR015685

Pfam

Pfam Accession	Pfam ID
PF00230	MIP	Major intrinsic protein

KEGG

Bile secretion

OMIM

602914

Interactions

STRING	MINT	I2D

Associated Diseases

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Diseases	References
Edema	20126625

References

Primary:

PMID: 17924462

[Expression of aquaporin 9 in granulosa cells of patients with polycystic ovary syndrome in IVF-cycles].

Lu Xiu-e, Qian Yu-li, Huang He-feng

The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Sep;36(5):449-53.