APOC1

Gene Information
 
Gene Symbol
APOC1
 
Aliases
Apo-CI, ApoC-I
 
Entrez Gene ID
341
 
Gene Name
Apolipoprotein C-I
 
Chromosomal Location
19q13.2
 
HGNC ID
607
 
Summary
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006629 Biological process Lipid metabolic process TAS 2897845
GO:0010873 Biological process Positive regulation of cholesterol esterification TAS 18992221
GO:0010900 Biological process Negative regulation of phosphatidylcholine catabolic process IDA 2302419
GO:0010916 Biological process Negative regulation of very-low-density lipoprotein particle clearance IDA 1917954
GO:0032374 Biological process Regulation of cholesterol transport IC 15576844
Protein Information
 
Protein Name
Truncated apolipoprotein C-I
 
Function
Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR006781
 
Pfam
Pfam Accession Pfam ID
PF04691 ApoC-I Apolipoprotein C-I (ApoC-1)
 
OMIM

Associated Diseases

Diseases References
Cardiovascular risk 22197663
   
References
 
Primary:

Dyslipidemia in PCOS.

Wild Robert A
Oklahoma University Health Sciences Center, Oklahoma City, OK, United States. Robert-Wild@ouhsc.eduoma
Steroids. 2012 Mar 10;77(4):295-9. doi: 10.1016/j.steroids.2011.12.002. Epub 2011
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ApoCIII and ApoCII 
Dysfunction and potential cardiovascular risk 
 
 
Related 
 
ApoCI was higher in PCOS group 

 

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