AKT1

Gene Information
 
Gene Symbol
AKT1
 
Aliases
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
 
Entrez Gene ID
207
 
Gene Name
V-akt murine thymoma viral oncogene homolog 1
 
Chromosomal Location
14q32.33
 
HGNC ID
391
 
Summary
 
GeneCards ID
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0000060 Biological process Protein import into nucleus, translocation IMP 16280327
GO:0001934 Biological process Positive regulation of protein phosphorylation IDA 19057511
GO:0001938 Biological process Positive regulation of endothelial cell proliferation IMP 19850054
GO:0005979 Biological process Regulation of glycogen biosynthetic process IMP 8940145
GO:0006464 Biological process Cellular protein modification process TAS 10570282
Protein Information
 
Protein Name
RAC-alpha serine/threonine-protein kinase
 
Function
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00069 Pkinase Protein kinase domain
PF00169 PH PH domain
PF00433 Pkinase_C Protein kinase C terminal domain
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Endometrial hyperplasia 22455688
Uterine leiomyomas and endometriosis 21916800
   
References
 
Primary:

[Activation and significance of the PI3K/Akt pathway in endometrium with polycystic ovary syndrome patients].

Zhang Hui-ying, Zhang Yan-fang, Han Yu-kun, Xue Feng-xia, Zhao Xiao-hui, Zhang Xiu-lan
Department of Obstetrics and Gynecology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Zhonghua Fu Chan Ke Za Zhi. 2012 Jan;47(1):19-23.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
PI3K 
Endometrial hyperplasia and carcinoma 
 
 
Related 
 
The PI3K/Akt pathway was over activated in endometrium with PCOS which may be associated with the formation of endometrial hyperplasia and carcinoma in PCOS patients. 
CDK2, Cyclin E, p27 and Ras 
Hyperplasia 
Ser473-AKT phosphorylation 
Rotterdam criteria 
Related 
 
The PCOS condition is associated with increased Ser473-AKT phosphorylation, elevated expression of Ras, increased cytoplasmic abundance of p27, and increased nuclear abundance of CDK2 in the endometrial epithelial cells. These biological events could potentially provide a chance for endometrial cells from PCOS patients to exit the controlled cell cycle and become hyperplastic at a later stage 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
23426873
Prenatal androgen excess programs metabolic derangements in pubertal female rats. 
Animal study 
22538004
In vivo oocyte IGF-1 priming increases inner cell mass proliferation of in vitro-formed bovine blastocysts. 
Animal study 
21190977
Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells. 
Effect of treatment 

 

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