AKR1C2

Gene Information
 
Gene Symbol
AKR1C2
 
Aliases
AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
 
Entrez Gene ID
 
Gene Name
Aldo-keto reductase family 1, member C2
 
Chromosomal Location
10p15-p14
 
HGNC ID
385
 
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (provided by RefSeq)
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006693 Biological process Prostaglandin metabolic process IDA 8573067
GO:0007586 Biological process Digestion IDA 8573067
GO:0008202 Biological process Steroid metabolic process IDA 8573067
GO:0031406 Molecular function Carboxylic acid binding IDA 8573067
GO:0032052 Molecular function Bile acid binding IDA 8573067
Protein Information
 
Protein Name
Aldo-keto reductase family 1 member C2
 
Function
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00248 Aldo_ket_red Aldo/keto reductase family
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000370129

Associated Diseases

Diseases References
Cancer 15929998, 17283174, 12539226, 18508192, 12604227
   
References
 
Primary:

The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.

Wang Lihua, Li Shengxian, Zhao Aimin, Tao Tao, Mao Xiuying, Zhang Ping, Liu Wei
Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):120-6. Epub 2012 Feb 21.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
22381227
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients. 
Clinical study 

 

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