AGT

Gene Information
 
Gene Symbol
AGT
 
Aliases
ANHU, SERPINA8
 
Entrez Gene ID
183
 
Gene Name
Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
 
Chromosomal Location
1q42.2
 
HGNC ID
333
 
Summary
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001558 Biological process Regulation of cell growth NAS 17159080
GO:0001819 Biological process Positive regulation of cytokine production TAS 17906677
GO:0001822 Biological process Kidney development IMP 16116425
GO:0001974 Biological process Blood vessel remodeling TAS 10406457
GO:0002016 Biological process Regulation of blood volume by renin-angiotensin NAS 17159080
Protein Information
 
Protein Name
Angiotensin 1-4
 
Function
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2| Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone| Angiotensin-3 stimulates aldosterone release| Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity)
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00079 Serpin Serpin (serine protease inhibitor)
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions

Associated Diseases

Diseases References
Cardiovascular diseases 11345362, 16033904, 16531750, 16513650
Diabetes mellitus 1828024, 9893168
Diabetes mellitus insulin-dependent 10499884
Edema 12899344, 12567432, 11256235
Glomerulosclerosis 10619595, 18421480, 7714817
   
References
 
Primary:

The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome.

Zulian Elisa, Sartorato Paola, Schiavi Francesca, Moghetti Paolo, Castello Roberto, Mantero Franco, Opocher Giuseppe, Scaroni Carla
Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy.
Fertil Steril. 2005 Nov;84(5):1520-1.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26407537
Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent. 
Clinical study 
22475072
Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis. 
Effect of treatment 
20655529
Clinically useful predictors of conversion to abnormal glucose tolerance in women with polycystic ovary syndrome. 
Clinical study 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412