ADRB3

Gene Information
 
Gene Symbol
ADRB3
 
Aliases
BETA3AR
 
Entrez Gene ID
155
 
Gene Name
Adrenoceptor beta 3
 
Chromosomal Location
8p12
 
HGNC ID
288
 
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. (provided by RefSeq, Feb 2009)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0002032 Biological process Desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0005975 Biological process Carbohydrate metabolic process TAS 2570461
GO:0006091 Biological process Generation of precursor metabolites and energy TAS 2570461
GO:0006112 Biological process Energy reserve metabolic process TAS 1718744
GO:0006898 Biological process Receptor-mediated endocytosis IDA 15123695
Protein Information
 
Protein Name
Beta-3 adrenergic receptor
 
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00001 7tm_1 7 transmembrane receptor (rhodopsin family)
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Hyperandrogenism 11287026
Polycystic ovary syndrome (PCOS) 21756250
   
References
 
Primary:

Candidate gene analysis in premature pubarche and adolescent hyperandrogenism.

Witchel S F, Smith R, Tomboc M, Aston C E
Division of Pediatric Endocrinology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania, Pittsburgh 15213, USA. witches@chplink.chp.edu
Fertil Steril. 2001 Apr;75(4):724-30.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
CYP21 mutations,HSD3B2 variants,IRS-1, GRL 
Hyperandrogenism 
ADRB3 variants 
 
Related 
 
Our findings suggest that the development of PP and HA can be associated with the occurrence of multiple sequence variants at five susceptibility loci, especially steroidogenic enzyme genes. 

 

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