ADRB2

Gene Information
 
Gene Symbol
ADRB2
 
Aliases
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
 
Entrez Gene ID
154
 
Gene Name
Adrenoceptor beta 2, surface
 
Chromosomal Location
5q31-q32
 
HGNC ID
286
 
Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
RefSeq DNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0002032 Biological process Desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0006898 Biological process Receptor-mediated endocytosis IDA 15123695
GO:0007166 Biological process Cell surface receptor signaling pathway TAS 1371121
GO:0007171 Biological process Activation of transmembrane receptor protein tyrosine kinase activity TAS 10734107
GO:0007188 Biological process Adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 2823249
Protein Information
 
Protein Name
Adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor
 
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00001 7tm_1 7 transmembrane receptor (rhodopsin family)
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Insulin resistance 16779985
   
References
 
Primary:

Association of polymorphisms in the beta2 and beta3 adrenoceptor gene with polycystic ovary syndrome.

Kurabayashi Takumi, Yahata Tetsuro, Quan Jinhua, Tanaka Kenichi
Department of Obstetrics and Gynecology, Niigata City General Hospital and Niigata University School of Medicine, Niigata, Japan. takumi@hosp.niigata.niigata.jp
J Reprod Med. 2006 May;51(5):389-93.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
BAR-3 
Insulin resistance 
Polymorphism in codon 27 (Gln27Glu) of BAR-2 
 
Direct 
Japanese-59 infertile PCOS & 97 healthy controls 
The polymorphism in codon 27 (Gln27Glu) of BAR-2 is linked to the expression of PCOS in Japanese women 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25218925
Enhanced insulin sensitivity and acute regulation of metabolic genes and signaling pathways after a single electrical or manual acupuncture session in female insulin-resistant rats. 
Effect of treatment 
22900502
Association between ??2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. 
Clinical study 

 

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