ADIPOR2

Gene Information
 
Gene Symbol
ADIPOR2
 
Aliases
ACDCR2, PAQR2
 
Entrez Gene ID
 
Gene Name
Adiponectin receptor 2
 
Chromosomal Location
12p13
 
HGNC ID
 
Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 (PubMed 12802337)).(supplied by OMIM)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0009755 Biological process Hormone-mediated signaling pathway ISS 12802337
GO:0019395 Biological process Fatty acid oxidation ISS 12802337
GO:0042562 Molecular function Hormone binding ISS 12802337
Protein Information
 
Protein Name
Adiponectin receptor protein 2
 
Function
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR004254
 
Pfam
Pfam Accession Pfam ID
PF03006 HlyIII Haemolysin-III related
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Anorexia nervosa 17391161
Atherosclerosis 20178558
Cancer 19723917, 17123704, 19524379, 19723917, 19661131
Cardiovascular diseases 16756736
Diabetes mellitus 19336949
   
References
 
Primary:

Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.

Tan B K, Chen J, Digby J E, Keay S D, Kennedy C R, Randeva H S
Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Diabetologia. 2006 Nov;49(11):2723-8. Epub 2006 Sep 26.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
AdipoR1 
 
 
 
Related 
16 PCO, 9 controls 
A significantly lower proportion of theca cells expressed adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) in polycystic ovaries than in normal ovaries. These results provide evidence for a direct link between fat cell metabolism and ovarian steroidogenesis, suggesting that disruption of adiponectin and/or its receptors plays a key role in pathogenesis of hyperandrogenism in PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26197851
Endometria from Obese PCOS Women with Hyperinsulinemia Exhibit Altered Adiponectin Signaling. 
In vitro 
25963796
Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or ??-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome. 
Effect of treatment 
24335000
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome. 
Clinical study 
23875783
Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome. 
Effect of treatment 
23779096, PMC3725221
Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells. 
In vitro 

 

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